351523-06-3

Basic information

• Product Name: (2R,3R,3aS,9aR)-7-Methyl-3-(tetrahydro-pyran-2-yloxy)-2-(tetrahydro-pyran-2-yloxymethyl)-2,3,3a,9a-tetrahydro-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one
• Synonyms: (2R,3R,3aS,9aR)-7-Methyl-3-(tetrahydro-pyran-2-yloxy)-2-(tetrahydro-pyran-2-yloxymethyl)-2,3,3a,9a-tetrahydro-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one
• CAS NO: 351523-06-3
• Molecular Weight: 408.452
• Mol File: 351523-06-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2R,3R,3aS,9aR)-7-Methyl-3-(tetrahydro-pyran-2-yloxy)-2-(tetrahydro-pyran-2-yloxymethyl)-2,3,3a,9a-tetrahydro-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R,3aS,9aR)-7-Methyl-3-(tetrahydro-pyran-2-yloxy)-2-(tetrahydro-pyran-2-yloxymethyl)-2,3,3a,9a-tetrahydro-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one(351523-06-3)
• EPA Substance Registry System: (2R,3R,3aS,9aR)-7-Methyl-3-(tetrahydro-pyran-2-yloxy)-2-(tetrahydro-pyran-2-yloxymethyl)-2,3,3a,9a-tetrahydro-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one(351523-06-3)

Safety Data

• Hazardous Substances Data: 351523-06-3(Hazardous Substances Data)

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 22423-26-3 O-2,2'-cyclo-5-methyluridine 

Downstream Products

• 1054489-94-9 tert-butyl 5-methyl-2,6-dioxo-3-((2R,3S,4R,5R)-4-(tetrahydro-2H-pyran-2-yloxy)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)-3-(2-(tosyloxy)ethoxy)tetrahydrofuran-2-yl)-2,3-dihydropyrimidine-1(6H)-carboxylate 
• 1054490-24-2 2-(3-((2R,3S,4R,5R)-3-(tert-butoxycarbonyloxy)-4-(tetrahydro-2H-pyran-2-yloxy)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)tetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl 4-methylbenzenesulfonate 
• 351523-11-0 1-[(2R,3S,4R,5R)-3-Benzyloxy-4-(tetrahydro-pyran-2-yloxy)-5-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 122799-38-6 1-(2'-deoxy-2'-fluoro-β-D-ribofuranosyl)-5-methyluracil 

Relevant articles and documents

NUCLEOSIDE BASED PROLIFERATION IMAGING MARKERS

Disclosed herein are novel radiolabeled nucleosides and methods for detecting cellular proliferation in a mammal, the method comprising administrating an effective amount of a radiolabeled nucleoside; the method comprising: a) administering to the mammal a diagnostically effective amount of the nucleoside to the mammal; b) allowing the nucleoside to distribute into the effective tissue; and c) imaging the tissue, wherein an increase in binding of the compound to tissue compared to a normal control level of binding indicates that the mammal is suffering from a disease involving cellular proliferation.

Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors

Highly selective arabinofuranosyl nucleosides, which inhibit the mitochondrial thymidine kinase (TK-2) without affecting the closely related herpes simplex virus type 1 thymidine kinase (HSV-1 TK), varicella-zoster virus thymidine kinase (VZV-TK), cytosolic thymidine kinase (TK-1) or the multifunctional Drosophila melanogaster deoxyribonucleoside kinase (Dm-dNK), have been obtained. SAR studies indicate a close relation between the length of the substituent at the 2′ position of the arabinofuranosyl moiety and the inhibitory activity.