351528-80-8

Basic information

• Product Name: 6-Fluoro-3(2H)-benzofuranone
• Synonyms: 6-Fluoro-3(2H)-benzofuranone;6-Chloro-3-Benzofuranone;3(2H)-Benzofuranone,6-fluoro-(9CI);6-Fluorobenzofuran-3(2H)-one;6-Fluoro-1-benzofuran-3(2H)-one, 2,3-Dihydro-6-fluoro-3-oxobenzo[b]furan;6-Fluorobenzo[b]furan-3(2H)-one 98+%;6-Fluoro-benzofuran-3-one;6-Fluoro-2,3-dihydrobenzofuran-3-one
• CAS NO: 351528-80-8
• Molecular Formula: C₈H₅FO₂
• Molecular Weight: 168.5771
• Product Categories: HALIDE
• Mol File: 351528-80-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 261.7±40.0 °C(Predicted)
• Appearance: /
• Density: 1.379±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-Fluoro-3(2H)-benzofuranone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Fluoro-3(2H)-benzofuranone(351528-80-8)
• EPA Substance Registry System: 6-Fluoro-3(2H)-benzofuranone(351528-80-8)

Safety Data

• Hazardous Substances Data: 351528-80-8(Hazardous Substances Data)

Usage

General Description

6-Fluoro-3(2H)-benzofuranone, also known as 6-Fluorobenzofuranone, is a chemical compound with the molecular formula C8H5FO2. It is a fluorinated benzofuranone derivative with a six-membered ring, and it is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. This chemical is known for its potential as a herbicide, pesticide, or fungicide due to its ability to inhibit certain enzymes in plants and microorganisms. It is also used in the production of fragrances and flavoring agents due to its aromatic properties. Additionally, 6-Fluoro-3(2H)-benzofuranone is used as a research tool in the study of various biological processes due to its unique chemical structure.

Upstream product

• 1481-27-2 4-Fluoro-2-hydroxyacetophenone 
• 404-98-8 3-fluorophenoxyacetic acid 
• 372-20-3 3-fluorophenol 
• 95299-69-7 2-(3-fluorophenoxy)acetyl chloride 

Downstream Products

• 857062-24-9 tert-butyl-[2-(4-chloro-phenyl)-6-fluoro-benzofuran-3-yloxy]-dimethyl-silane 
• 857062-22-7 2-(4-chloro-phenyl)-6-fluoro-benzofuran-3-one 
• 870652-82-7 6-aminobenzofuran-3(2H)-one 

Relevant articles and documents

Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect islet β-cells from apoptosis

Death-associated protein kinase-related apoptosis-inducing kinase-2 (DRAK2) is a serine/threonine kinase that plays a key role in a wide variety of cell death signaling pathways. Inhibition of DRAK2 was found to efficiently protect islet β-cells from apoptosis and hence DRAK2 inhibitors represent a promising therapeutic strategy for the treatment of diabetes. Only very few chemical entities targeting DRAK2 are currently known. We carried out a high throughput screening and identified compound 4 as a moderate DRAK2 inhibitor with an IC50value of 3.15?μM. Subsequent SAR studies of hit compound 4 led to the development of novel benzofuran-3(2H)-one series of DRAK2 inhibitors with improved potency and favorable selectivity profiles against 26 selected kinases. Importantly, most potent compounds 40 (IC50?=?0.33?μM) and 41 (IC50?=?0.25?μM) were found to protect islet β-cells from apoptosis in dose-dependent manners. These data support the notion that small molecule inhibitors of DRAK2 represents a promising strategy for the treatment of diabetes.