351536-44-2

Basic information

• Product Name: (E)-1,1,1-Trichloro-4-cyclohexyl-but-3-en-2-ol
• Synonyms: (E)-1,1,1-Trichloro-4-cyclohexyl-but-3-en-2-ol
• CAS NO: 351536-44-2
• Molecular Weight: 257.587
• Mol File: 351536-44-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-1,1,1-Trichloro-4-cyclohexyl-but-3-en-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1,1,1-Trichloro-4-cyclohexyl-but-3-en-2-ol(351536-44-2)
• EPA Substance Registry System: (E)-1,1,1-Trichloro-4-cyclohexyl-but-3-en-2-ol(351536-44-2)

Safety Data

• Hazardous Substances Data: 351536-44-2(Hazardous Substances Data)

Upstream product

• 2043-61-0 cyclohexanecarbaldehyde 
• 42134-55-4 (E)-3-cyclohexyl-2-propen-1-ol 
• 17343-88-3 (E)-3-cyclohexyl-acrylic acid ethyl ester 
• 351536-28-2 tert-butyl-(3-cyclohexyl-1-trichloromethyl-allyloxy)-dimethyl-silane 

Relevant articles and documents

Kinetic resolution of acyclic secondary allylic silyl ethers catalyzed by chiral ketones

Kinetic resolution of acyclic secondary allylic silyl ethers by chiral dioxiranes generated in situ from chiral ketones (R)-1 and (R)-2 and Oxone was investigated. An efficient and catalytic method has been developed for kinetic resolution of those substrates with a CCl3, tert-butyl, or CF3 group at the α-position. In particular, high selectivities (S up to 100) were observed for kinetic resolutions of racemic α-trichloromethyl allylic silyl ethers 7 and 9-15 catalyzed by ketones (R)-2. Both the recovered substrates and the resulting epoxides were obtained in high enantiomeric excess. On the basis of steric and electrostatic interactions between the chiral dioxiranes and the racemic substrates, a model was proposed to rationalize the enantioselectivities and diastereoselectivities in the chiral ketone-catalyzed kinetic resolution process.