35155-04-5Relevant academic research and scientific papers
2-Acyl-6-aminomethylphenol derivatives
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, (2008/06/13)
A 2-acyl-6-aminomethylphenol derivative having the formula (I): STR1 wherein R1 represents a straight chain or branched chain alkyl group of 1 to 6 carbon atoms unsubstituted or substituted with 1 to 3 halogen atoms; a hydrogen atom or a group having the formula (II): wherein n represents 0 or an integer of 1 to 6; R7 represents a cycloalkyl group of 3 to 8 carbon atoms unsubstituted or substituted with at least one lower alkyl group; a phenyl group unsubstituted or substituted with at least one lower alkyl group, a halogen atom, a lower alkoxy group or a lower alkylthio group; a lower alkoxy group; a lower alkylthio group; a lower alkylsulfinyl group; a lower alkylsulfonyl group; an N-lower alkylamino group; an N,N-di-lower alkylamino group; or a pyridyl, furyl or thienyl group; R2 represents a straight chain or branched chain alkyl group of 1 to 6 carbon atoms; a cycloalkyl group of 4 to 8 carbon atoms unsubstituted or substituted with at least one lower alkyl group; a phenyl group unsubstituted or substituted with at least one lower alkyl group, a lower alkoxy group, a lower alkylthio group or a halogen atom; or a lower alkylthio group; R3 and R4 each represents a hydrogen atom or R2 and R3 or R2 and R4 when taken together represent an alkylene group of 2 to 5 carbon atoms unsubstituted or substituted with 1 or 2 lower alkyl groups; R5 represents a hydrogen atom or a lower alkyl group; and R6 represents a hydrogen atom, a lower alkyl group or an acyl group, and the pharmaceutically acceptable acid addition salt thereof having anti-inflammatory, analgesic, antipyretic, diuretic and hypotensive effects that can be used for preventing and curing diseases caused by inflammation, edema, hypertension, etc. are disclosed. Also disclosed is a process for preparing such derivative or a pharmaceutically acceptable acid addition salt thereof.
