3516-80-1

Basic information

• Product Name: 4-Benzolazo-phenylacetaldehyd
• CAS NO: 3516-80-1
• Molecular Weight: 224.262
• Mol File: 3516-80-1.mol

Chemical Properties

• CAS DataBase Reference: 4-Benzolazo-phenylacetaldehyd(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Benzolazo-phenylacetaldehyd(3516-80-1)
• EPA Substance Registry System: 4-Benzolazo-phenylacetaldehyd(3516-80-1)

Safety Data

• Hazardous Substances Data: 3516-80-1(Hazardous Substances Data)

Upstream product

• 3516-74-3 <4-Benzolazo-phenacetyl>-malonsaeure-diethylester 
• 104-10-9 2-(4'-aminophenyl)ethyl alcohol 
• 586-96-9 Nitrosobenzene 

Downstream Products

• 1586819-16-0 C₂₈H₃₂N₄O 

Relevant articles and documents

A photochromic agonist for μ-opioid receptors

Opioid receptors (ORs) are widely distributed in the brain, the spinal cord, and the digestive tract and play an important role in nociception. All known ORs are G-protein-coupled receptors (GPCRs) of family A. Another well-known member of this family, rhodopsin, is activated by light through the cis/trans isomerization of a covalently bound chromophore, retinal. We now show how an OR can be combined with a synthetic azobenzene photoswitch to gain light sensitivity. Our work extends the reach of photopharmacology and outlines a general strategy for converting Family A GPCRs, which account for the majority of drug targets, into photoreceptors. Lighting up the opioid receptor: Photofentanyl-2 is a photochromic version of the well-known analgesic fentanyl. It is a potent agonist in the dark (or when illuminated with blue light) and loses activity when irradiated with UV light. It can be used to optically control the μ-opioid receptor, converting a G-protein-coupled receptor (GPCR) into a photoreceptor.