35160-04-4

Upstream product

• 106991-89-3 N,N'-dibenzyl-5,5'-dinitro-2,2'-disulfanediyl-bis-benzamide 
• 92030-46-1 5,5'-dinitro-2,2'-disulfanediyl-bis-benzoyl chloride 
• 100-46-9 benzylamine 
• 83909-69-7 N-benzyl-2-chloro-5-nitrobenzamide 

Downstream Products

• 92905-96-9 2-benzyl-5-nitro-1,1-dioxo-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-one 

Relevant academic research and scientific papers

Preparation of benzisothiazolones from 2-bromobenzamides and sulfur under copper catalysis conditions

A convenient two-stage method has been developed for preparing benz[d]isothiazol-3(2H)-ones from 2-bromobenzamides and sulfur in a one-pot process under copper catalysis conditions. The method is suitable for the synthesis of N-aryl-, benzyl-, and alkyl-substituted benzisothiazolones. The yields of the benzisothiazolones depend on the nature of the starting amide and can reach 91%.

An efficient copper mediated synthetic methodology for benzo[d]isothiazol- 3(2H)-ones and related sulfur-nitrogen heterocycles

A copper mediated sulfur-nitrogen coupling reaction for the synthesis of benzo[d]isothiazol-3(2H)-ones and related sulfur-nitrogen heterocycles has been presented, which requires 2-halo-arylamides, sulfur powder, 25-50 mol % of copper iodide/1,10-phenanthroline, and potassium carbonate as base.