83909-69-7Relevant articles and documents
Covalent Occlusion of the RORγt Ligand Binding Pocket Allows Unambiguous Targeting of an Allosteric Site
Meijer, Femke A.,Van Den Oetelaar, Maxime C. M.,Doveston, Richard G.,Sampers, Ella N. R.,Brunsveld, Luc
supporting information, p. 631 - 639 (2021/04/07)
The nuclear receptor RORγt is a key positive regulator in the differentiation and proliferation of T helper 17 (Th17) cells and the production of proinflammatory cytokines like IL-17a. Dysregulation of this pathway can result in the development of various
Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasis
Hwang, Jong Yeon,Smithson, David,Connelly, Michele,Maier, Julie,Zhu, Fangyi,Guy, Kiplin R.
supporting information; experimental part, p. 149 - 152 (2010/04/29)
A series of halo-nitrobenzamide were synthesized and evaluated for their ability to block proliferation of Trypanosoma brucei brucei. A number of these compounds had significant activity against the parasite, particularly 2-chloro-N-(4-chlorophenyl)-5-nitrobenzamide 17 which exhibited low micromolar inhibitory potency against T. brucei and selectivity towards both malaria and mammalian cells.
PREPARATION OF 5-NITROBENZOISOTHIAZOLONE AND ITS N-DERIVATIVES.
PONCI,BARUFFINI,CROCI,GIALDI
, p. 732 - 749 (2007/10/08)
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