83909-69-7

Upstream product

• 25784-91-2 2-chloro-5-nitrobenzoylchloride 
• 100-46-9 benzylamine 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 

Downstream Products

• 147642-50-0 3-amino-2-benzyl-7-nitro-4-(2-quinolyl)-1,2-dihydroisoquinolin-1-one 
• 136146-77-5 3-Amino-2-benzyl-4-(3-methoxy-phenyl)-7-nitro-2H-isoquinolin-1-one 
• 136146-80-0 3-Amino-2-benzyl-4-(4-fluoro-phenyl)-7-nitro-2H-isoquinolin-1-one 
• 83909-66-4 N-Benzyl-2-(cyclohexylamino)-5-nitrobenzamide 
• 130653-42-8 N-Benzyl-2-butylamino-5-nitro-benzamide 
• 135408-64-9 3-Amino-2-benzyl-4-(1-methyl-1H-benzoimidazol-2-yl)-7-nitro-2H-isoquinolin-1-one 
• 130653-36-0 N-Benzyl-2-methylamino-5-nitro-benzamide 
• 117821-51-9 N-Benzyl-2-cyclohexyloxy-5-nitro-benzamide 
• 147642-48-6 3-Amino-2-benzyl-4-(4-methyl-thiazol-2-yl)-7-nitro-2H-isoquinolin-1-one 
• 117821-75-7 5-Amino-N-benzyl-2-cyclohexyloxy-benzamide; hydrochloride 
• 1256846-45-3 2-benzyl-5-nitrobenzo[d][1,2]selenazol-3(2H)-one 
• 35160-04-4 2-benzyl-5-nitrobenzo[d]isothiazol-3(2H)-one 
• 13156-81-5 N-benzyl-2-hydroxy-5-nitrobenzamide 
• 1421846-55-0 10-benzyl-6-chloro-2-nitrodibenzo[b,f][1,4]thiazepin-11(10H)-one 

Relevant academic research and scientific papers

Covalent Occlusion of the RORγt Ligand Binding Pocket Allows Unambiguous Targeting of an Allosteric Site

The nuclear receptor RORγt is a key positive regulator in the differentiation and proliferation of T helper 17 (Th17) cells and the production of proinflammatory cytokines like IL-17a. Dysregulation of this pathway can result in the development of various

A highly efficient copper-catalyzed method for the synthesis of 2-hydroxybenzamides in water

An efficient copper-catalyzed synthetic method for the preparation of 2-hydroxybenzamides is described for the first time from 2-chlorobenzamide substrates using copper iodide/1,10-phenanthroline and a base, potassium hydroxide, in neat water. By using this reaction, a series of 2-hydroxybenzamides with functional groups such as fluoro, chloro, iodo, methoxy, amide, and alcohol have been obtained in 33-96% yield. Other aromatic 2-chloroarylamides such as naphthalene, pyridine, and thiophene are found to be equally compatible to the reaction. It is proposed that the reaction proceed via formation of copper-amide complex, which may facilitate the hydroxylation in water. Overall, the first report on copper-catalyzed hydroxylation reaction in water and first catalytic route for the synthesis of 2-hydroxybenzamides is presented. Simple purification procedure and convenience of employing low-cost reagents in neat water make this method practical and economical for the synthesis of 2-hydroxybenzamides. Georg Thieme Verlag Stuttgart · New York.

Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasis

A series of halo-nitrobenzamide were synthesized and evaluated for their ability to block proliferation of Trypanosoma brucei brucei. A number of these compounds had significant activity against the parasite, particularly 2-chloro-N-(4-chlorophenyl)-5-nitrobenzamide 17 which exhibited low micromolar inhibitory potency against T. brucei and selectivity towards both malaria and mammalian cells.