35166-37-1

Usage

Uses

Used in Scientific Research:
3-(Chloromethyl)-5-methylisoxazole is used as a research compound for studying its chemical properties and potential applications in various fields of chemistry.
Used in Chemical Synthesis:
3-(Chloromethyl)-5-methylisoxazole is used as a synthetic intermediate for the production of other complex organic compounds, contributing to the development of new materials and pharmaceuticals.
Used in Pharmaceutical Industry:
3-(Chloromethyl)-5-methylisoxazole is used as a building block in the synthesis of pharmaceuticals, potentially contributing to the development of new drugs and therapeutic agents.

InChI:InChI=1/C5H6ClNO/c1-4-2-5(3-6)7-8-4/h2H,3H2,1H3

Upstream product

• 3209-72-1 ethyl 5-methylisoxazole-3-carboxylate 
• 35166-33-7 (5-methyl-isoxazol-3-yl)-methanol 

Downstream Products

• 145441-07-2 3-(2,6-dimethylphenoxymethyl)-5-methyl-3-isoxazole 
• 57612-87-0 (5-methyl-1,2-oxazol-3-yl)acetic acid 
• 344886-74-4 2-(5-Methyl-isoxazol-3-ylmethoxy)-phenol 
• 74704-94-2 N-(5-methyl-3-isoxazolylmethyl)-2,6-dimethylaniline 
• 172475-36-4 1-<(5-Methylisoxazol-3-yl)methyl>pyrazole 
• 100960-41-6 2-amino-3-(5-methyl-isoxazol-3-yl)-propionic acid 
• 632627-96-4 3-{2-[5-bromo-2-(5-methyl-isoxazol-3-ylmethoxy)phenyl]-5-methyl-pyrrol-1-yl}-benzoic acid ethyl ester 
• 313679-66-2 C₃₁H₄₁N₃O₉S 
• 80073-32-1 5-methyl-3-isoxazolepropanoic acid 
• 35166-41-7 2-(5-methylisoxazol-3-yl)acetonitrile 
• 1044822-28-7 methyl 4-(chloromethyl)-6-methyl-2-phenyl-2H-1,3-oxazine-2-carboxylate 

Relevant academic research and scientific papers

SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF

Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.

5-lipoxygenase-activating protein (FLAP) inhibitors. Part 4: Development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin- 2-ylmethoxy)-1 H -indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor

The potent 5-lipoxygenase-activating protein (FLAP) inhibitor 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2- ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid 11cc is described (AM803, now GSK2190915). Building upon AM103 (1) (Hutchinson et al. J. Med Chem.2009, 52, 5803-5815; Stock et al. Bioorg. Med. Chem. Lett. 2010, 20, 213-217; Stock et al. Bioorg. Med. Chem. Lett.2010, 20, 4598-4601), SAR studies centering around the pyridine moiety led to the discovery of compounds that exhibit significantly increased potency in a human whole blood assay measuring LTB4 inhibition with longer drug preincubation times (15 min vs 5 h). Further studies identified 11cc with a potency of 2.9 nM in FLAP binding, an IC50 of 76 nM for inhibition of LTB4 in human blood (5 h incubation) and excellent preclinical toxicology and pharmacokinetics in rat and dog. 11cc also demonstrated an extended pharmacodynamic effect in a rodent bronchoalveolar lavage (BAL) model. This compound has successfully completed phase 1 clinical studies in healthy volunteers and is currently undergoing phase 2 trials in asthmatic patients.

Substituted enaminones, their derivatives and uses thereof

The present invention is related substituted enaminones represented by a compound of Formula I that are novel allosteric modulators of α7 nAChRs. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine a

Antibacterial monic acid derivatives

A compound of the formula (I) STR1 wherein R is a group STR2 R1 is hydrogen, phenyl, C1-20 alkyl, C2-8 alkenyl or C2-8 alkynyl each of which may optionally be substituted; or C3-7 cycloalkyl, X is a divalent group --Y--C=C--, and Y is oxygen or sulphur, have antibacterial and/or antimycoplasmal activity.

Di-heterocyclic compounds and their use as antiviral agents

Compounds of the formulas: STR1 wherein Het is an oxazole or oxazine moiety; X is O, S or SO, n is an integer from 3 to 9, Y is an aliphatic bridge; and the various R groups represent hydrogen or various substituents as described herein, are useful as antiviral agents, especially against picornaviruses. N-(Chloroalkyl)amide intermediates for the compounds of Formula I are also active as antiviral agents. Related compounds outside the scope of the above formulas are also disclosed.

Isoxazoles as antiviral agents

Compounds of the formulas: STR1 wherein R is alkyl, X is O or CH2, n is an integer from 4 to 8, and Ar is phenyl or substituted phenyl are useful as antiviral agents especially against picornaviruses.

PHARMACOLOGICALLY ACTIVE GUANIDINE COMPOUNDS

The compounds are substituted thioalkyl-, aminoalkyl-and oxyalkyl-guanidines which are inhibitors of histamine activity.