57612-87-0

Usage

Category

Synthetic antioxidant

Common applications

Food preservation
Personal care products preservation

Derivation

Derived from phenol and isopropyl alcohol

Purpose

Prevents oxidation and spoilage in products like oils, fats, and processed foods

Health concerns

Classified as a possible human carcinogen by the International Agency for Research on Cancer (IARC)
Linked to potential health risks such as skin irritation and hormone disruption

Controversy

Subject to debate due to potential adverse health effects

Regulations

Some countries have imposed restrictions on the use of BHA in food and cosmetics

Upstream product

• 35166-37-1 3-chloromethyl-5-methylisoxazole 
• 35166-41-7 2-(5-methylisoxazol-3-yl)acetonitrile 
• 143-33-9 sodium cyanide 
• 60148-50-7 (5-methyl-isoxazol-3-yl)-acetic acid ethyl ester 

Downstream Products

• 130403-07-5 N-(2,6-Dimethyl-phenyl)-2-(5-methyl-isoxazol-3-yl)-acetamide 
• 1024012-64-3 C₂₅H₂₆N₆O₂ 

Relevant academic research and scientific papers

Novel Imidazo[4,5-c]Quinoline And Imidazo[4,5-c][1,5]Naphthyridine Derivatives As LRRK2 Inhibitors

The present invention provides novel imidazo[4,5-c]quinoline and imidazo[4,5-c][1,5]naphthyridine derivatives of Formula (I), and the pharmaceutically acceptable salts thereof wherein R1, R1a, R1b, R2, R4, R5, R6, X and Z are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of Formula (I) and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy.

PEPTIDE EPOXYKETONE COMPOUNDS

The present disclosure relates to novel compounds and pharmaceutical compositions thereof which are useful as inhibitors of proteasomes. The compounds provided herein are capable of inhibiting all three of CT-L, T-L, and PGPH activities of proteasomes, and are useful in treating various conditions or diseases associated with proteasomes.

Substituted enaminones, their derivatives and uses thereof

The present invention is related substituted enaminones represented by a compound of Formula I that are novel allosteric modulators of α7 nAChRs. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine a

New N-aryl isoxazolecarboxamides and N-isoxazolylbenzamides as anticonvulsant agents

We prepared a series of N-aryl isoxazolecarboxamide, N-isoxazolylbenzamide compounds and derivatives and studied their anticonvulsant action in MES and MMS tests. Some of these reveal considerable activity, especially with respect to MES test. The disubstitution in the 2.6-position on the phenyl ring by two methyl groups would appear to be of primary importance for the activity. The amide bridge between the phenyl and isoxazolic rings, whether of the anilide or benzamide type, seems to show similar anticonvulsant behavior. We have selected the derivatives 8 (N-(2.6-dimethylphenyl)-5-methyl-3-isoxazolecarboxamide, 12 (N-(2.6-dimethylphenyl)-5-hydroxymethyl-3-isoxazolecarboxamide) and 51 (N-(5-methyl-3-isoxazolyl)-2.6-dimethylbenzamide) which are presently being studied in more extended pharmacological tests.