3517-42-8Relevant articles and documents
TRANSFORMED STEROIDS. 176. PATHS OF TRANSFORMATION OF 17α-ETHYNYL-17β-HYDROXYANDROSTENES INTO Δ16-21-HYDROXY-20-KETOPREGNENES
Turuta, A. M.,Fadeeva, T. M.,Kamernitskii, A. V.,Chi, Lu Dyk
, p. 2574 - 2579 (1989)
A novel method in steroid chemistry for synthesis of pregna-4,16-dien-3-one-20-yne and pregna-5,16-dien-3β-ol-20-yne, based on the dehydration of Co-complexes of the corresponding 17α-ethynyl-17β-carbinols was investigated.The theoretical possibility of using phenyliodoso trifluoroacetate for the preparative transformation Δ16-17-ethynyl steroids into 21-hydroxy-Δ16-20-ketopregnanes was discovered.
FACILE SYNTHESIS OF CORTICOSTEROIDS FROM 17-KETOSTEROIDS VIA 20-CYANO-21-CARBOXYLATES
Gumulka, Maria,Kurek, Alicja,Wicha, Jerzy
, p. 741 - 748 (2007/10/02)
Introduction of the dihydroxyacetone side chain at position 17 of steroidal skeleton via cyanocarbalkoxymethylidene derivatives is described.The latter compounds were obtained by condensation of corresponding 17-oxoandrostanes with ethyl cyanoacetate.Synthesis of 17α,21-dihydroxypregn-4-ene-3,20-dione 21-acetate (Reichstein's substance S acetate) is presented.Syntheses of model 17-deoxycorticosteroids from 17-cyanocarbalkoxymethylidene derivatives were carried out.