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3-beta,17-alpha,21-trihydroxypregn-5-en-20-one 21-acetate, also known as hydrocortisone acetate, is a synthetic corticosteroid derived from the naturally occurring hormone cortisol. It is a white crystalline powder with a molecular formula of C23H32O6 and a molecular weight of 404.5 g/mol. This chemical is primarily used as an anti-inflammatory and immunosuppressive agent in pharmaceuticals, treating conditions such as rheumatoid arthritis, lupus, and various skin disorders. Hydrocortisone acetate is administered topically, orally, or by injection, depending on the specific medical need. It works by mimicking the effects of cortisol in the body, reducing inflammation, suppressing the immune system, and alleviating symptoms associated with various inflammatory and autoimmune conditions.

1474-10-8

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1474-10-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1474-10-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,7 and 4 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1474-10:
(6*1)+(5*4)+(4*7)+(3*4)+(2*1)+(1*0)=68
68 % 10 = 8
So 1474-10-8 is a valid CAS Registry Number.
InChI:InChI=1/C23H34O5/c1-14(24)28-13-20(26)23(27)11-8-19-17-5-4-15-12-16(25)6-9-21(15,2)18(17)7-10-22(19,23)3/h4,16-19,25,27H,5-13H2,1-3H3/t16-,17+,18-,19-,21-,22-,23-/m0/s1

1474-10-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name [2-[(3S,8R,9S,10R,13S,14S,17R)-3,17-dihydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate

1.2 Other means of identification

Product number -
Other names EINECS 216-015-2

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1474-10-8 SDS

1474-10-8Relevant academic research and scientific papers

FACILE SYNTHESIS OF CORTICOSTEROIDS FROM 17-KETOSTEROIDS VIA 20-CYANO-21-CARBOXYLATES

Gumulka, Maria,Kurek, Alicja,Wicha, Jerzy

, p. 741 - 748 (2007/10/02)

Introduction of the dihydroxyacetone side chain at position 17 of steroidal skeleton via cyanocarbalkoxymethylidene derivatives is described.The latter compounds were obtained by condensation of corresponding 17-oxoandrostanes with ethyl cyanoacetate.Synthesis of 17α,21-dihydroxypregn-4-ene-3,20-dione 21-acetate (Reichstein's substance S acetate) is presented.Syntheses of model 17-deoxycorticosteroids from 17-cyanocarbalkoxymethylidene derivatives were carried out.

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