351890-40-9Relevant academic research and scientific papers
Efficient synthesis of (±)-seco-cyclopropaneindoline analogs of CC-1065
Jennings, Sharon A.,Toth, James L.,Roller, Shane G.,Brooks, Natalie,O'Hare, Caroline,Kiakos, Konstantinos,Hartley, John A.,Burke, Philip J.,Lee, Moses
, p. 7 - 16 (2007/10/03)
An efficient method for the preparation of racemic seco-cyclopropaneindoline, or seco-CI, analogs of the anticancer agent CC1065 is described. The syntheses of seco-CI compounds containing either 5,6,7-trimethoxyindole-2-carbonyl, 4, or 5-(benzofuran-2-carboxamido)indole-2-carbonyl, 10, or 2-(4-N,N-diethyl)aminophenyl)benzimidazole-6-carbonyl, 11, or 4-(4-butanamido-1-methylpyrrole-2-carboxamido)-1-methylpyrrole-2-carbonyl, 12, subunit are detailed. At μM concentrations, compounds 4, 10-12 inhibited the growth of human leukemic K562 cells in culture.
