351892-30-3

Basic information

• Product Name: 5-nitro-2-(o-tolyl)benzo[d]oxazole
• Synonyms: 5-nitro-2-(o-tolyl)benzo[d]oxazole
• CAS NO: 351892-30-3
• Molecular Weight: 254.245
• Mol File: 351892-30-3.mol

Chemical Properties

• CAS DataBase Reference: 5-nitro-2-(o-tolyl)benzo[d]oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-nitro-2-(o-tolyl)benzo[d]oxazole(351892-30-3)
• EPA Substance Registry System: 5-nitro-2-(o-tolyl)benzo[d]oxazole(351892-30-3)

Safety Data

• Hazardous Substances Data: 351892-30-3(Hazardous Substances Data)

Upstream product

• 10403-47-1 2-bromo 5-nitroaniline 
• 933-88-0 ortho-toluoyl chloride 
• 529-20-4 2-methylphenyl aldehyde 
• 99-57-0 2-hydroxy-5-nitroaniline 

Relevant articles and documents

Iridium-catalyzed intramolecular C–N and C–O/S cross-coupling reactions: Preparation of benzoazole derivatives

The irdium-catalyzed intramolecular arylcarbon-hetero cross-coupling reactions with o-haloarylamides or o-haloarylamidine have been effectively achieved using KOAc and just 1 mol% catalyst. The [Ir(cod)Cl]2 was proved to be more potential for smoothly assembling functional structures benzimidazoles, benzoxazoles and benzothiazoles, which was superior to Cu- and Pd-catalyzed systems. Simultaneously, a concise and efficient synthesis of tafamidis was developed in 5-g scale.

Preparation method of 2-phenylbenzoxazole compound

The invention relates to a preparation method of a 2-phenylbenzoxazole compound, comprising the following steps: (1) condensation reaction: a 2-amino phenol compound and a benzoyl chloride compound, which are used as raw materials, react in an organic solvent to obtain a condensation reaction solution; and (2) cyclization reaction: as a cyclization catalyst, acid is added into the condensation reaction solution to carry out a cyclization reaction at a certain temperature so as to obtain a cyclization reaction solution; after the reaction, an organic solvent is added for heating refluxing; andcooling filtration or liquid-separation condensation is finally carried out to obtain a 2-phenylbenzoxazole compound. The technology is simple; product post-treatment is simple; environmental pollution is less; the prepared 2-phenylbenzoxazole compound has high product quality and good stability; in addition to general use purpose, the prepared product also can be used for preparation of a high-end luminescent material; and the preparation method is a method suitable for industrial preparation.

Efficient aerobic oxidative synthesis of 2-substituted benzoxazoles, benzothiazoles, and benzimidazoles catalyzed by 4-Methoxy-TEMPO

(Chemical Equation Presented) Setting the TEMPO: The scheme shows the efficient aerobic synthesis of 2-substituted benzoxazoles, benzothiazoles, and benzimidazoles where 4-methoxy-2,2,6,6-tetramethyl-1-piperidinyloxy free radical (4-Methoxy-TEMPO) is used as the catalyst.