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351900-97-5

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351900-97-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 351900-97-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,1,9,0 and 0 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 351900-97:
(8*3)+(7*5)+(6*1)+(5*9)+(4*0)+(3*0)+(2*9)+(1*7)=135
135 % 10 = 5
So 351900-97-5 is a valid CAS Registry Number.

351900-97-5Relevant articles and documents

Synthetic studies of complex immunostimulants from Quillaja saponaria: Synthesis of the potent clinical immunoadjuvant QS-21Aapi

Kim, Yong-Jae,Wang, Pengfei,Navarro-Villalobos, Mauricio,Ronde, Bridget D.,Derryberry, JohnMark,Gin, David Y.

, p. 11906 - 11915 (2007/10/03)

QS-21 is one of the most promising new adjuvants for immune response potentiation and dose-sparing in vaccine therapy given its exceedingly high level of potency and its favorable toxicity profile. Melanoma, breast cancer, small cell lung cancer, prostate cancer, HIV-1, and malaria are among the numerous maladies targeted in more than 80 recent and ongoing vaccine therapy clinical trials involving QS-21 as a critical adjuvant component for immune response augmentation. QS-21 is a natural product immunostimulatory adjuvant, eliciting both T-cell- and antibody-mediated immune responses with microgram doses. Herein is reported the synthesis of QS-21 Aapi in a highly modular strategy, applying novel glycosylation methodologies to a convergent construction of the potent saponin immunostimulant. The chemical synthesis of QS-21 offers unique opportunities to probe its mode of biological action through the preparation of otherwise unattainable nonnatural saponin analogues.

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