850004-42-1

Basic information

• Product Name: O-trichloroacetimidoyl-[(2-O-benzoyl-3,4,6-tri-O-benzyl-β-D-galactopyranosyl)-(1->2)]-O-[(2,3,4-tri-O-benzyl-β-D-xylopyranosyl)-(1->3)]-6-O-methyl-4-O-acetyl-α-D-glucuronate
• Synonyms: O-trichloroacetimidoyl-[(2-O-benzoyl-3,4,6-tri-O-benzyl-β-D-galactopyranosyl)-(1->2)]-O-[(2,3,4-tri-O-benzyl-β-D-xylopyranosyl)-(1->3)]-6-O-methyl-4-O-acetyl-α-D-glucuronate
• CAS NO: 850004-42-1
• Molecular Weight: 1333.71
• Mol File: 850004-42-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: O-trichloroacetimidoyl-[(2-O-benzoyl-3,4,6-tri-O-benzyl-β-D-galactopyranosyl)-(1->2)]-O-[(2,3,4-tri-O-benzyl-β-D-xylopyranosyl)-(1->3)]-6-O-methyl-4-O-acetyl-α-D-glucuronate(CAS DataBase Reference)
• NIST Chemistry Reference: O-trichloroacetimidoyl-[(2-O-benzoyl-3,4,6-tri-O-benzyl-β-D-galactopyranosyl)-(1->2)]-O-[(2,3,4-tri-O-benzyl-β-D-xylopyranosyl)-(1->3)]-6-O-methyl-4-O-acetyl-α-D-glucuronate(850004-42-1)
• EPA Substance Registry System: O-trichloroacetimidoyl-[(2-O-benzoyl-3,4,6-tri-O-benzyl-β-D-galactopyranosyl)-(1->2)]-O-[(2,3,4-tri-O-benzyl-β-D-xylopyranosyl)-(1->3)]-6-O-methyl-4-O-acetyl-α-D-glucuronate(850004-42-1)

Safety Data

• Hazardous Substances Data: 850004-42-1(Hazardous Substances Data)

Upstream product

• 351900-87-3 methyl 4-O-acetyl-3-O-(tert-butyldimethylsilyl)-glucuronate-D-glycal 
• 351900-86-2 methyl 3-O-(tert-butyldimethylsilyl)-glucuronate-D-glycal 
• 95530-80-6 methyl 1,2-dideoxy-D-arabino-hex-1-enopyranuronate 
• 148926-02-7 2-O-benzoyl-3,4,6-tri-O-benzyl-D-galactopyranose 
• 73445-31-5 benzoyl 3,4,6-tri-O-benzyl-2-O-benzoyl-β-D-galactopyranoside 
• 18039-26-4 2,3,4-tri-O-benzyl-D-xylopyranose 
• 80040-79-5 3,4,6-tri-O-benzyl-D-galactal 
• 57690-62-7 methyl 3,4-di-O-acetyl-1,2-dideoxy-D-arabino-hex-1-enopyranuronate 
• 351900-96-4 O-4-methoxybenzyl-O-[(2-O-benzoyl-3,4,6-tri-O-benzyl-β-D-galactopyranosyl)-(1->2)]-6-O-methyl-4-O-acetyl-3-O-(tert-butyldimethylsilyl)-β-D-glucuronate 
• 351900-92-0 O-4-methoxybenzyl-6-O-methyl-4-O-acetyl-3-O-(tert-butyldimethylsilyl)-β-D-glucuronate 
• 351900-88-4 methyl 1,2-anhydro-4-O-acetyl-3-O-(tert-butyldimethylsilyl)-α-D-glucuronate 
• 850004-60-3 O-4-methoxybenzyl-[(2-O-benzoyl-3,4,6-tri-O-benzyl-β-D-galactopyranosyl)-(1->2)]-O-[(2,3,4-tri-O-benzyl-β-D-xylopyranosyl)-(1->3)]-6-O-methyl-4-O-acetyl-β-D-glucuronate 
• 351900-97-5 O-4-methoxybenzyl-O-[(2-O-benzoyl-3,4,6-tri-O-benzyl-β-D-galactopyranosyl)-(1->2)]-6-O-methyl-4-O-acetyl-β-D-glucuronate 
• 545-06-2 trichloroacetonitrile 

Relevant articles and documents

Synthetic studies of complex immunostimulants from Quillaja saponaria: Synthesis of the potent clinical immunoadjuvant QS-21Aapi

QS-21 is one of the most promising new adjuvants for immune response potentiation and dose-sparing in vaccine therapy given its exceedingly high level of potency and its favorable toxicity profile. Melanoma, breast cancer, small cell lung cancer, prostate cancer, HIV-1, and malaria are among the numerous maladies targeted in more than 80 recent and ongoing vaccine therapy clinical trials involving QS-21 as a critical adjuvant component for immune response augmentation. QS-21 is a natural product immunostimulatory adjuvant, eliciting both T-cell- and antibody-mediated immune responses with microgram doses. Herein is reported the synthesis of QS-21 Aapi in a highly modular strategy, applying novel glycosylation methodologies to a convergent construction of the potent saponin immunostimulant. The chemical synthesis of QS-21 offers unique opportunities to probe its mode of biological action through the preparation of otherwise unattainable nonnatural saponin analogues.