352-61-4

Basic information

• Product Name: 5,5,5-TRIFLUOROPENTAN-1-OL
• Synonyms: 5,5,5-TRIFLUORO-1-PENTANOL;5,5,5-TRIFLUOROPENTAN-1-OL;1-Pentanol, 5,5,5-trifluoro-
• CAS NO: 352-61-4
• Molecular Formula: C₅H₉F₃O
• Molecular Weight: 142.12
• Mol File: 352-61-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 147.75 °C
• Appearance: /
• Density: 1.137±0.06 g/cm3(Predicted)
• PKA: 15.02±0.10(Predicted)
• CAS DataBase Reference: 5,5,5-TRIFLUOROPENTAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 5,5,5-TRIFLUOROPENTAN-1-OL(352-61-4)
• EPA Substance Registry System: 5,5,5-TRIFLUOROPENTAN-1-OL(352-61-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 352-61-4(Hazardous Substances Data)

Usage

Uses

5,5,5-Trifluoro-1-pentanol is used to prepare sulfonamide compounds as TRPM8 receptor modulators useful in treatment of diseases.

Upstream product

• 50-00-0 formaldehyd 
• 406-81-5 1-Bromo-4,4,4-trifluorobutane 
• 407-62-5 5,5,5-trifluoropentanoic acid 
• 22581-21-1 5,5,5-trifluoro-pent-3t-en-1-ol 
• 352-59-0 5-Chlor-1,1,1-trifluor-pentan 

Downstream Products

• 407-62-5 5,5,5-trifluoropentanoic acid 
• 1185898-21-8 5,5,5-trifluoropentanetyl 4-methylbenzenesulfonate 

Relevant articles and documents

PYRAZOLE COMPOUNDS

The present invention relates to wherein each symbol is as defined in the specification. The compound has a superior mineralocorticoid receptor antagonistic action and is useful as an agent for the prophylaxis or treatment of a disease or condition mediated by the mineralocorticoid receptor activation.

Pyrazolo[3,4-b]pyridine carboxylic acid esters and their pharmaceutical use

Compounds of the formula (I): STR1 wherein R1, R3, R4, R5 and R6 have defined values and the N-oxides at the 7-position of the pyrazolo[3,4-b]pyridine ring system and the pharmaceutically-acceptable acid-addition salts thereof, processes for their preparation and use, pharmaceutical compositions, and intermediates for preparing said compounds of the formula (I). The compounds of formula (I) are central nervous system depressants, for example anxiolytic agents.