35202-54-1

Basic information

• Product Name: 4,5-Dimethoxy-1-cyanobenzocyclobutane
• Synonyms: 3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile;4,5-Dimethoxy-1-benzocyclobutenecarbonitrile;4,5-Dimethoxy-1-cyanobenzocyclobutane;3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-8-carbonitrile;Bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile,3,4-diMethoxy-;4,5-DiMethxoy-1,2-dihydrocyclobutabenzene-1-carbonitrile;2-cyclobutyl-2-(3,4-diMethoxyphenyl)acetonitrile;1,2-Dihydro-4,5-diMethoxybenzocyclobutene-1-carbonitrile
• CAS NO: 35202-54-1
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.21
• EINECS: 1592732-453-0
• Mol File: 35202-54-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 83-84 °C
• Boiling Point: 345.9 °C at 760 mmHg
• Flash Point: 140.5 °C
• Appearance: /
• Density: 1.18
• Vapor Pressure: 5.98E-05mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO, Methanol
• CAS DataBase Reference: 4,5-Dimethoxy-1-cyanobenzocyclobutane(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Dimethoxy-1-cyanobenzocyclobutane(35202-54-1)
• EPA Substance Registry System: 4,5-Dimethoxy-1-cyanobenzocyclobutane(35202-54-1)

Safety Data

• Hazardous Substances Data: 35202-54-1(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 35202-54-1 differently. You can refer to the following data:
1. 4,5-Dimethoxy-1-cyanobenzocyclobutane is used in the preparation of selective bradycardic agents.
2. 4,5-Dimethoxy-1-benzocyclobutenecarbonitrile is used in the preparation of selective bradycardic agents.

InChI:InChI=1/C11H11NO2/c1-13-10-4-7-3-8(6-12)9(7)5-11(10)14-2/h4-5,8H,3H2,1-2H3

Upstream product

• 37895-73-1 1,2-dibromo-4,5-dimethoxybenzene 
• 91-16-7 1,2-dimethoxybenzene 
• 55171-76-1 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-one 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 
• 53207-00-4 1-bromo-2-(bromomethyl)-4,5-dimethoxybenzene 
• 37629-85-9 (2E)-3-(3,4-dimethoxyphenyl)prop-2-enenitrile 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 49621-56-9 3-(3,4-dimethoxyphenyl)propanenitrile 
• 1214788-46-1 (R)-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile 
• 35249-62-8 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile 
• 7721-62-2 4,5-dimethoxy-2-methylbenzaldehyde 
• 84452-13-1 7-Chloro-3,4-dimethoxy-bicyclo[4.2.0]octa-1⁽⁶⁾,2,4-triene 
• 1232191-48-8 2-(2-cyanoethyl)-4,5-dimethoxyphenyl dimethylsulphamate 

Downstream Products

• 35202-55-2 1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride 
• 148870-56-8 ({3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl)(methyl)amine 
• 155974-00-8 ivabradine 
• 41234-23-5 (R,S)-4,5-dimethoxy-1,2-dihydrocyclobutabenzene-1-carboxylic acid 
• 55171-70-5 3,4-Dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid amide 
• 866783-12-2 [{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine 
• 1220993-43-0 (7S)-3,4-dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide 
• 1086026-31-4 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-(methyl)amino]propyl}-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 
• 148849-67-6 ivabradine hydrochloride 
• 866783-13-3 1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride 
• 73344-75-9 (±)-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methylamine 
• 96917-59-8 3,3-ethylenedioxy-1,2,3,4,4a,9,10,10aβ-octahydro-6,7-dimethoxy-10α-phenylsulfonylphenanthrene-4aβ-carbonitrile 
• 111674-97-6 3,3-ethylenedioxy-1,2,3,4,4a,9,10,10aβ-octahydro-6,7-dimethoxy-10α-phenylsulfinylphenanthrene-4aβ-carbonitrile 
• 111674-97-6 3,3-ethylenedioxy-1,2,3,4,4a,9,10,10aβ-octahydro-6,7-dimethoxy-10α-phenylsulfinylphenanthrene-4aβ-carbonitrile 

Relevant articles and documents

Process for the enzymatic synthesis of (7S)-3,4-dimethoxybicyclo[4.2.0]OCTA-1,3,5-triene-7-carboxylic acid and application in the synthesis of ivabradine and salts thereof

Process for the enzymatic synthesis of the compound of formula (I): comprising enantioselective enzymatic hydrolysis of the nitrile of formula (IV): using the nitrilase of Rhodococcus rhodochrous of EMBL accession number EF467367.1, and the application of such a process in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.

PROCESS FOR THE SYNTHESIS OF 3-(2-BROMO-4,5-DIMETHOXYPHENYL)PROPANENITRILE, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID

Process for the synthesis of the compound of formula (I): Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

PROCESS FOR THE SYNTHESIS OF 3-(2-BROMO-4,5-DIMETHOXYPHENYL)PROPANENITRILE, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID

Process for the synthesis of the compound of formula (I): Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.