352035-98-4

Usage

Uses

Used in Chemical Synthesis:
1-(3-BROMO-1-PROPYNYL)NAPHTHALENE is used as a reagent for the protection of alcohols in the form of a 1-naphthylpropargyl ether. This protection is crucial in chemical synthesis processes, as it prevents unwanted reactions with the alcohol functional group. The 1-naphthylpropargyl ether can be selectively cleaved with DDQ (2,3-dichloro-5,6-dicyano-1,4-benzoquinone), allowing for the controlled deprotection of the alcohol group when needed.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-(3-BROMO-1-PROPYNYL)NAPHTHALENE may be utilized as a key intermediate in the synthesis of various drug molecules. Its unique structure and reactivity make it a valuable building block for the development of new therapeutic agents.
Used in Research and Development:
1-(3-BROMO-1-PROPYNYL)NAPHTHALENE can also be employed in research and development settings, where it may be used to study the properties and reactivity of naphthalene-based compounds. This can lead to a better understanding of their potential applications and the development of new synthetic methods or strategies.

Upstream product

• 90-14-2 1-Iodonaphthalene 
• 90-11-9 1-Bromonaphthalene 
• 16176-22-0 3-(naphthalene-1-yl)prop-2-yn-1-ol 

Downstream Products

• 1015098-70-0 2-methylene-4-phenylpent-4-enyl 3-(1-naphthyl)prop-2-ynyl ether 
• 1166181-85-6 methyl 2-[2-(4-benzyloxyphenyl)ethyl]-5-(1-naphthyl)pent-4-ynoate 
• 917894-72-5 7-phenylphenanthro[2,3-c]furan-8(10H)-one 
• 917894-71-4 4-(naphthalen-1-yl)-naphtho[2,3-c]furan-1(3H)-one 
• 1606985-90-3 diethyl (Z)-(1-(benzylamino)-5-(naphthalen-1-yl)-1-phenylpent-1-en-4-yn-2-yl)phosphonate 
• 1606986-19-9 diethyl (E)-(1-(benzylamino)-5-(naphthalen-1-yl)-1-phenylpent-1-en-4-yn-2-yl)phosphonate 
• 1332362-23-8 (2S,3S)-2-(((3-(naphthalen-1-yl)prop-2-yn-1-yl)oxy)methyl)-3-phenyloxirane 

Relevant academic research and scientific papers

Antitubercular Bis-Substituted Cyclam Derivatives: Structure-Activity Relationships and in Vivo Studies

We recently reported the discovery of nontoxic cyclam-derived compounds that are active against drug-resistant Mycobacterium tuberculosis. In this paper we report exploration of the structure-activity relationship for this class of compounds, identifying

CARBOXYLIC DERIVATIVES FOR USE IN THE TREATMENT OF CANCER

The invention provides novel compounds of formula (I), wherein: R1 is a radical derived from one of the known ring systems; R2 is a phenyl radical optionally substituted; Xn represents a birradical selected from the group consisting of: -(CH2)1-4-, (C2-C4)-alkenyl, (C2-C4)alkynyl, -S-(CH2)1-3-#, and -(CH2)1-3-O-#; wherein the symbol # indicates the position at which Xn is attached to R1; Yn is a birradical selected from the group consisting of: -(CH2)2-4-, -S-(CH2)1-3#, and -O-(CH2)1-3-#,; where in the symbol # indicates the position at which Yn is attached to R2; and R3 is a radical selected from the group consisting of: -OR4. The compounds of formula (I) are useful in the treatment of cancer

1-Naphthylpropargyl ether group: A readily cleaved and sterically minimal protecting system for stereoselective glycosylation

(Chemical Equation Presented) The (1-naphthyl)propargyl group is introduced as a sterically unobtrusive alcohol protecting group that is cleaved in a single step by exposure to dichlorodicyanoquinone in wet dichloromethane. In conjunction with the 4,6-O-b

Rhodium(l)-catalyzed carbonyl allenylation versus propargylation via redox transmetalation across tetragonal tin(ll) oxide

A reagent combination of β-SnO and catalytic [Rh(COD)Cl]2 in THF-H2O promotes the reaction of propargyl bromides and aldehydes and directs the regioselectivity toward the formation of either allenic alcohols or homopropargylic alcohols. This highly regioselective either/or transformation proceeds via a transmetalation from rhodium to tin, in which metallotropic rearrangement between a propargylmetal and allenylmetal is arrested.