35205-61-9Relevant academic research and scientific papers
Asymmetric Hydrogenation of ?-Aryl Alkylidene Malonate Esters: Installing an Ester Group Significantly Increases the Efficiency
Zhao, Qian-Kun,Wu, Xiong,Li, Lin-Ping,Yang, Fan,Xie, Jian-Hua,Zhou, Qi-Lin
, p. 1675 - 1680 (2021/03/08)
Herein, we report a practical method for efficient asymmetric hydrogenation of β-aryl alkylidene malonates. With a site-specifically tailored chiral spiro iridium catalyst, a series of β-aryl alkylidene malonate esters were hydrogenated to afford chiral m
Zinc-mediated addition of diethyl bromomalonate to alkynes for the cascade reaction towards polysubstituted pyranones and tetracarbonyl derivatives
Miersch, Anne,Harms, Klaus,Hilt, Gerhard
supporting information, p. 542 - 544 (2014/01/06)
The zinc-mediated regioselective addition reactions of diethyl bromomalonate and aromatic and aliphatic alkynes were investigated for the synthesis of vinyl malonates. When the vinyl organo-zinc intermediates were reacted with acid chlorides 2H-pyran-2-ones were obtained while the application of oxalyl chloride and an amine led to tetracarbonyl derivatives in a one-pot multi-step reaction sequence. The Royal Society of Chemistry 2014.
Efficient palladium-catalyzed cross-coupling of β-chloroalkylidene/ arylidene malonates using microwave chemistry
Poondra, Rajamohan R.,Fischer, Peter M.,Turner, Nicholas J.
, p. 6920 - 6922 (2007/10/03)
A general method for the synthesis of β-aryl/ alkylarylidene malonates is reported. The key step involves the coupling of an arylboronic acid to a β-chloroalkyl/ arylidene malonate, in the presence of K2CO 3 and 1 mol % of the air-stable palladium catalyst (POPd) under microwave irradiation, to afford β-aryl/alkylarylidene malonates in good yields. The combination of mild reaction conditions, air stable catalyst, microwave-enhanced chemistry, and high levels of functional group compatibility make this an attractive synthetic approach to this class of compounds.
