35214-95-0Relevant academic research and scientific papers
Novel one-pot total syntheses of deoxyvasicinone, mackinazolinone, isaindigotone, and their derivatives promoted by microwave irradiation
Liu, Ji-Feng,Ye, Ping,Sprague, Kevin,Sargent, Katie,Yohannes, Daniel,Baldino, Carmen M.,Wilson, Christopher J.,Ng, Shi-Chung
, p. 3363 - 3366 (2007/10/03)
(Chemical Equation Presented) Total syntheses of deoxyvasicinone (1), mackinazolinone (2), and 8-hydroxydeoxyvasicinone (3) via novel microwave-assisted domino reactions, as well as a novel three-component one-pot total synthesis of isaindigotone (5) promoted by microwave irradiation, are reported. The efficient reaction process enabled us to rapidly access related natural product derivatives and to identify a new class of cytotoxic agents.
SYNTHETIC ANALOGS OF Peganum ALKALOIDS. I. SYNTHESIS OF METHOXY- AND HYDROXY-SUBSTITUTED DEOXYVASICINONES AND DEOXYPEGANINES
Karimov, A.,Telezhenetskaya, M. V.,Yunusov, S. Yu.
, p. 466 - 472 (2007/10/02)
6-Methoxy-, 7-methoxy-, and 8-methoxydeoxyvasicinones have been synthesized by the reaction of substituted (3-methoxy-, 4-methoxy-, and 5-methoxy-) anthranilic acids with α-pyrrolidone.The demethylation of these compounds has given the corresponding hydroxy-substituted analogs of deoxyvasicinone, and the reduction of the products obtained with zinc in hydrochloric acid has given the hydroxy- and methoxy- analogs of deoxypeganine. 8-Hydrooxydeoxypeganine dimethyl-, ethyl-, and butylcarbamates have been obtained by the carbamoylation of 8-hydroxydeoxypeganine.
Bacterial Constituents, X. - 5-Hydroxydeoxyvasicinone, a Pyrroloquinazolone Derivative from Klebsiella
Mohr, Nikolaus,Budzikiewicz, Herbert,Korth, Heinz,Pulverer, Gerhard
, p. 1515 - 1518 (2007/10/02)
From the culture filtrate of Klebsiella pneumoniae var. oxytoca 3-hydroxyanthranilic acid and 2,3-dihydro-5-hydroxypyrroloquinazoline-9(1H)-one (4b) (= 5-hydroxydeoxyvasicinone) could be isolated.
