352196-63-5

Upstream product

• 27895-95-0 2-bromo-1,2-bis(4-methoxyphenyl)ethanone 
• 536-90-3 m-Anisidine 
• 2132-62-9 4,4'-dimethoxydiphenylacetylene 
• 855-38-9 P(p-CH₃OC₆H₄)3 
• 75-04-7 ethylamine 
• 352196-60-2 2[ethyl-(3-methoxyphenyl)amino]-1,2-bis(4-methoxyphenyl)ethanone 
• 352196-56-6 1,2-bis(4-methoxyphenyl)-2-[(3-methoxyphenyl)amino]ethanone 

Relevant academic research and scientific papers

Assembly of Indole Cores through a Palladium-Catalyzed Metathesis of Ar-X σ-Bonds

We describe the development of a new method for construction of highly substituted indole scaffolds through the strategic utilizing of the metathesis of Ar-X σ-bonds based on the dynamic nature of palladium-based oxidative addition/reductive elimination. A suitable and simple catalytic system has provided an appropriate platform for a productive ligand exchange and consecutive carbopalladation/C-H activation/amination of phosphine ligands with alkynes and aromatic/aliphatic amines for construction of structurally diverse indoles.

Ultrasound-promoted synthesis of 2,3-bis(4-hydroxyphenyl)indole derivatives as inherently fluorescent ligands for the estrogen receptor

A series of 2,3-bis(4-hydroxyphenyl)indole derivatives 4c-f was prepared by ultrasound-promoted intramolecular cyclodehydration of a polyphosphoric acid solution of α-anilinyl-(or 3-anisidyl)desoxyanisoins 2c-f, and their optical spectroscopy and estrogen receptor (ER) binding properties were studied. Compounds 4c-f give intense long-wavelength fluorescent emission, sensitive to solvent polarity and pH. Furthermore, the two indol-6-ols 4e, f display reasonably good binding affinities to ER and appear to be well suited for use as fluorescent probes for the detection of ER in cells.