352210-85-6Relevant academic research and scientific papers
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties
Li, Yan,Qiang, Xiaoming,Luo, Li,Yang, Xia,Xiao, Ganyuan,Zheng, Yunxiaozhu,Cao, Zhongcheng,Su, Fu,Deng, Yong,Sang, Zhipei
, p. 714 - 726 (2017)
A series of homoisoflavonoid Mannich base derivatives were designed, synthesized and evaluated as multifunctional agents against Alzheimer's disease. It demonstrated that most of the derivatives were selective AChE and MAO-B dual inhibitors with good mult
PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF
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Paragraph 00226; 00227, (2015/01/16)
The present invention relates to pyrazole compounds, and pharmaceutically acceptable compositions thereof, useful as positive allosteric modulators of follicle stimulating hormone receptor (FSHR).
Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction
Mahalingam, Poornachandran,Takrouri, Khuloud,Chen, Ting,Sahoo, Rupam,Papadopoulos, Evangelos,Chen, Limo,Wagner, Gerhard,Aktas, Bertal H.,Halperin, Jose A.,Chorev, Michael
, p. 5094 - 5111 (2014/07/08)
The 4EGI-1 is the prototypic inhibitor of eIF4E/eIF4G interaction, a potent inhibitor of translation initiation in vitro and in vivo and an efficacious anticancer agent in animal models of human cancers. We report on the design, synthesis, and in vitro ch
Synthesis and absolute configuration of (-)-neuchromenin, a neurotrophic metabolite of Eupenicillium javanicum var. meloforme, and its enantiomer
Tanada, Yoshihisa,Mori, Kenji
, p. 1963 - 1966 (2007/10/03)
Both the enantiomers of neuchromenin 1 (2,3-dihydro-8,9-dihydroxy-2-methyl-4H,5H-pyrano[3,2-c][1]benzopyran-4-one) were synthesized starting from the enantiomers of ethyl 3-hydoxybutanoate (7). The naturally occurring (-)-neuchromenin, a neurotrophic metabolite of Eupenicillium javanicum var. meloforme, was shown to be (S)-1.
