352233-13-7

Basic information

• Product Name: 4'-acetoxymethylpropiophenone
• Synonyms: 4'-acetoxymethylpropiophenone
• CAS NO: 352233-13-7
• Molecular Weight: 206.241
• Mol File: 352233-13-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4'-acetoxymethylpropiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-acetoxymethylpropiophenone(352233-13-7)
• EPA Substance Registry System: 4'-acetoxymethylpropiophenone(352233-13-7)

Safety Data

• Hazardous Substances Data: 352233-13-7(Hazardous Substances Data)

Upstream product

• 127-09-3 sodium acetate 
• 95889-09-1 1-(4-(bromomethyl)phenyl)propan-1-one 
• 5337-93-9 4'-methylpropiophenone 

Downstream Products

• 352233-17-1 (S)-1-(4-hydroxymethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one 
• 352233-15-9 (R)-1-(4-hydroxymethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one 
• 352233-12-6 1-[4-(hydroxymethyl)phenyl]propan-1-one 

Relevant articles and documents

Synthesis, resolution and absolute configuration of a tolperisone metabolite

1-(4′-Hydroxymethyl-phenyl)-2-methyl-3-(piperidine-1-yl)-propane-1-one M2, a metabolite of tolperisone, was synthesised in a solvent-free Mannich reaction. The optical resolution was carried out by diastereoisomeric salt formation and separation, for which three resolving agents ((2R,3R)-O,O′-dibenzoyl tartaric acid, (2R,3R)-O,O′-di-p-toluoyl tartaric acid and (R)-2-hydroxy-4-(2-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaphosphorinane-2- oxide (anicyphos)) were found. The absolute configuration of M2 was determined by the single-crystal X-ray diffraction method.