352278-00-3

Upstream product

• 57486-68-7 methyl (2-chlorophenyl)acetate 
• 84478-76-2 1-chloro-5-fluoro-2-methoxy-4-nitrobenzene 
• 1182402-74-9 methyl (5-chloro-4-methoxy-2-nitrophenyl)(2-chlorophenyl)acetate 
• 352277-98-6 N-(4-chloro-3-methoxyphenyl)-D,L-2-chloromandelamide 

Downstream Products

• 352278-02-5 5-chloro-3-(2-chlorophenyl)-3-hydroxy-6-methoxy-1,3-dihydro-2H-indol-2-one 
• 1182402-79-4 5-Chloro-3-(4-chlorobutyl)-3-(2-chlorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one 
• 1182402-78-3 5-Chloro-3-(2-chlorophenyl)-3-[4-(dimethylamino)butyl]-6-methoxy-1,3-dihydro-2H-indol-2-one 

Relevant academic research and scientific papers

NOVEL 3-AMINOALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF

The present invention relates to novel 3-aminoalkyl-1,3-dihydro-2H-indol-2-one derivatives, to their preparation and to their therapeutic application. The compounds of the present invention correspond to the formula (I): in which the variables are as set forth in the specification. These compounds exhibit a strong affinity and a high selectivity for human arginine-vasopressin (AVP) V1a receptors and some compounds additionally exhibit a strong affinity for AVP V1b receptors.

Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use

The invention relates to compounds of formula: and also to the salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, with affinity for and selectivity towards the arginine-vasopressin V1b receptors and/or for the ocytocin receptors and, furthermore, for certain compounds, affinity for the V1a receptors. The invention also relates to the process for preparing them, to the intermediate compounds of formula (IV) that are useful for preparing them, to pharmaceutical compositions containing them and to their use for preparing medicinal products.