84478-76-2

Basic information

• Product Name: 1-CHLORO-5-FLUORO-2-METHOXY-4-NITROBENZENE
• Synonyms: 2-CHLORO-4-FLUORO-5-NITROANISOLE;1-CHLORO-5-FLUORO-2-METHOXY-4-NITROBENZENE;4-Chloro-2-fluoro-5-methoxy-1-nitrobenzene;1-Chloro-5-fluoro-2-methoxy-4-nitrobenzene, 2-Chloro-4-fluoro-5-nitrophenyl methyl ether
• CAS NO: 84478-76-2
• Molecular Formula: C₇H₅ClFNO₃
• Molecular Weight: 205.57
• Mol File: 84478-76-2.mol

Chemical Properties

• Melting Point: 72-75°C
• Boiling Point: 307.9 °C at 760 mmHg
• Flash Point: 140 °C
• Appearance: /
• Density: 1.453
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-CHLORO-5-FLUORO-2-METHOXY-4-NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-5-FLUORO-2-METHOXY-4-NITROBENZENE(84478-76-2)
• EPA Substance Registry System: 1-CHLORO-5-FLUORO-2-METHOXY-4-NITROBENZENE(84478-76-2)

Safety Data

• Hazard Codes: Xi,C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• HazardClass: IRRITANT
• Hazardous Substances Data: 84478-76-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-CHLORO-5-FLUORO-2-METHOXY-4-NITROBENZENE is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be further modified and incorporated into complex molecular structures. Its presence in the molecular framework can contribute to the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 1-CHLORO-5-FLUORO-2-METHOXY-4-NITROBENZENE serves as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its unique combination of functional groups allows for the creation of compounds that can target and control various pests and weeds in agriculture.
Used in Dye and Pigment Production:
1-CHLORO-5-FLUORO-2-METHOXY-4-NITROBENZENE is also utilized as an intermediate in the manufacturing of dyes and pigments. Its chemical structure can be manipulated to produce a range of colors and properties suitable for various applications in the textile, paint, and printing industries.
Safety Note:
It is crucial to handle 1-CHLORO-5-FLUORO-2-METHOXY-4-NITROBENZENE with care due to its potential harmful effects if inhaled, ingested, or comes into contact with the skin. Proper safety measures, including the use of personal protective equipment and adherence to safety protocols, should be strictly followed during its handling and processing.

Upstream product

• 84478-75-1 2-chloro-4-fluoro-5-nitrophenol 
• 74-88-4 methyl iodide 

Downstream Products

• 1182402-94-3 tert-butyl 4-[3-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-fluoro-phenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]propyl]piperidin-1-carboxylate 
• 1182402-92-1 5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-fluorophenyl)-6-methoxy-3-(3-(piperidin-4-yl)propyl)-1,3-dihydro-2H-indol-2-one hydrochloride 
• 1188355-33-0 5-Chloro-3-(3-chloropropyl)-3-(2-fluorophenyl)-6-methoxy-1-{[4-(1-methyl-ethoxy)phenyl]sulfonyl}-1,3-dihydro-2H-indol-2-one 
• 1182402-84-1 5-Chloro-3-(2-fluorophenyl)-6-methoxy-3-[3-(4-methylpiperazin-1-yl)propyl]-1,3-dihydro-2H-indol-2-one 
• 1182402-80-7 5-Chloro-3-(2-fluorophenyl)-3-[3-(dimethylamino)propyl]-6-methoxy-1,3-dihydro-2H-indol-2-one 
• 1182402-78-3 5-Chloro-3-(2-chlorophenyl)-3-[4-(dimethylamino)butyl]-6-methoxy-1,3-dihydro-2H-indol-2-one 
• 1188354-96-2 tert-Butyl 4-[3-[5-chloro-3-(2-fluorophenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]propyl]piperidine-1-carboxylate 
• 1182402-81-8 5-Chloro-3-(3-chloropropyl)-3-(2-fluorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one 
• 1182402-79-4 5-Chloro-3-(4-chlorobutyl)-3-(2-chlorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one 
• 1182402-75-0 5-Chloro-3-(2-fluorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one 
• 352278-00-3 5-chloro-3-(2-chlorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one 
• 1182402-76-1 methyl (5-chloro-4-methoxy-2-nitrophenyl)(2-fluorophenyl)acetate 

Relevant articles and documents

ANTIBIOTIC COMPOUNDS

The present invention relates to antibiotic compounds of formula (I), to compositions containing these compounds and to methods of treating bacterial diseases and infections using the compounds. The compounds find application in the treatment of infection with, and diseases caused by, Gram-positive and/or Gram-negative bacteria, and in particular in the treatment of infection with, and diseases caused by, Neisseria gonorrhoeae.

ARYL AND HETEROARYL FUSED IMIDAZO[1,5-a]PYRAZINES AS INHIBITORS OF PHOSPHODIESTERASE 10

The invention relates to imidazo[1,5-a]pyrazine derivatives, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 10 (PDE10), as active compounds for treating central nervous system diseases of mammals, including humans.

Substituted piperazines

Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Substituted tricyclics

A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2mediated release of fatty acids for treatment of conditions such as septic shock.

Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitors

Novel tricyclics are disclosed together with the use of such compounds for inhibiting SPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.

Herbicidal 1-aryl-4-substituted-1,4-dihydro-5H-tetrazol-5-ones and sulfur analogs thereof

Herbicidal aryltetrazolinones and thiones of the formula STR1 in which W is oxygen or sulfur; R is alkyl, fluoroalkyl, alkenyl, haloalkenyl, cyanoalkyl, alkylthioalkyl, haloalkoxyalkyl, trifluoromethylthio or alkoxyalkyl; one of X1 and X2 is fluorine, chlorine, or bromine and the other is fluorine, chlorine, bromine, alkyl, nitro or haloalkyl; and Z is a group selected from a variety of substituents including 2-propynyloxy as disclosed and exemplified.

N-(2-Fluoro-4-halo-5-substituted phenyl) hydantoins

A composition comprising an N-(2-fluoro-4-halo-5-substituted phenyl) hydantoin of the formula: STR1 wherein X is a chlorine atom or a bromine atom and R1 and R2 are, same or different, each a C1 -C4 alkyl group, a cyclopropyl group, a C3 -C4 alkenyl group or a C3 -C4 alkynyl group and an inert carrier, which is useful as a herbicide.