352352-02-4

Upstream product

• 141215-69-2 methyl (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-(1H-indol-3-yl)propanoate 
• 98-59-9 p-toluenesulfonyl chloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 7524-52-9 (S)-tryptophan methyl ester hydrochloride 

Downstream Products

• 1026967-06-5 2-{2-[(2-tert-butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-3-phenyl-propionylamino}-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-propionic acid methyl ester 
• 639457-76-4 (S)-2-{(S)-2-[((S)-2-Acetylamino-4-methyl-pentanoyl)-methyl-amino]-3-phenyl-propionylamino}-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-propionic acid methyl ester 
• 639457-78-6 (S)-2-Acetylamino-4-methyl-pentanoic acid methyl-((S)-2-phenyl-1-{(E)-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-vinylcarbamoyl}-ethyl)-amide 
• 639457-77-5 (S)-2-Acetylamino-4-methyl-pentanoic acid methyl-((S)-2-phenyl-1-{(Z)-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-vinylcarbamoyl}-ethyl)-amide 

Relevant academic research and scientific papers

Selective Reductive Elimination at Alkyl Palladium(IV) by Dissociative Ligand Ionization: Catalytic C(sp3)?H Amination to Azetidines

A palladium(II)-catalyzed γ-C?H amination of cyclic alkyl amines to deliver highly substituted azetidines is reported. The use of a benziodoxole tosylate oxidant in combination with AgOAc was found to be crucial for controlling a selective reductive elimination pathway to the azetidines. The process is tolerant of a range of functional groups, including structural features derived from chiral α-amino alcohols, and leads to the diastereoselective formation of enantiopure azetidines.

Asymmetric and Geometry-Selective α-Alkenylation of α-Amino Acids

Both E- and Z-N′-alkenyl urea derivatives of imidazolidinones may be formed selectively from enantiopure α-amino acids. Generation of their enolate derivatives in the presence of K+ and [18]crown-6 induces intramolecular migration of the alkeny

Synthesis and cell cycle inhibition of the peptide enamide natural products terpeptin and the aspergillamides

Total syntheses of the peptide enamide natural products terpeptin and aspergillamides A and B are reported. An oxidative decarboxylation-elimination protocol is employed to construct the indolic enamide moiety. Unambiguous stereochemical assignment of (-)-terpeptin is accomplished by synthesis of all possible stereochemical analogues. Select compounds have been evaluated in cell cycle inhibitor assays which show that the natural amino acid configuration of terpeptin has the most potent inhibitory activity.