3524-31-0

Basic information

• Product Name: 1-(PYRIDIN-4-YLMETHYL)-1H-PYRAZOL-5-AMINE
• Synonyms: 1-(pyridin-4-ylmethyl)-1H-pyrazol-5-amine(SALTDATA: FREE)
• CAS NO: 3524-31-0
• Molecular Formula: C9H10N4
• Molecular Weight: 174.21
• Mol File: 3524-31-0.mol

Chemical Properties

• Boiling Point: 411.8°Cat760mmHg
• Flash Point: 202.8°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 5.43E-07mmHg at 25°C
• Refractive Index: 1.663
• PKA: 5.38±0.10(Predicted)
• CAS DataBase Reference: 1-(PYRIDIN-4-YLMETHYL)-1H-PYRAZOL-5-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(PYRIDIN-4-YLMETHYL)-1H-PYRAZOL-5-AMINE(3524-31-0)
• EPA Substance Registry System: 1-(PYRIDIN-4-YLMETHYL)-1H-PYRAZOL-5-AMINE(3524-31-0)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 3524-31-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(PYRIDIN-4-YLMETHYL)-1H-PYRAZOL-5-AMINE is used as a key component in the development of new drugs and bioactive compounds due to its unique chemical structure and reactivity. It plays a crucial role in the creation of diverse molecular entities with varied properties and functions, contributing to the advancement of medicinal chemistry.
Used in Organic Synthesis:
In the field of organic synthesis, 1-(PYRIDIN-4-YLMETHYL)-1H-PYRAZOL-5-AMINE is utilized as a valuable building block. Its distinctive structure and reactivity make it instrumental in the synthesis of complex organic molecules, facilitating the development of novel chemical entities with potential applications across various industries.

InChI:InChI=1/C9H10N4/c10-9-3-6-12-13(9)7-8-1-4-11-5-2-8/h1-6H,7,10H2

Upstream product

• 872-85-5 pyridine-4-carbaldehyde 
• 353-07-1 3-hydrazinylpropanenitrile 
• 329264-80-4 C₉H₁₀N₄ 

Relevant articles and documents

PYRAZOLOPYRIMIDINES AS INHIBITORS OF GLUCOCORTICOID RECEPTOR TRANSLOCATION

Provided herein are compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of Glucocorticoid Receptor (GR) translocation. Furthermore, the subject compounds and compositions are useful for the treatment of diseases involved in the hypothalamic-pituitary-adrenal (HPA) axis.

TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R1, R2 and R3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.

Approach to the library of fused pyridine-4-carboxylic acids by combes-type reaction of acyl pyruvates and electron-rich amino heterocycles

A library of fused pyridine-4-carboxylic acids (including pyrazolo[3,4-b]pyridines, isoxazolo[5,4-b]pyridines, furo[2,3-b]pyridines, thieno[2,3-b]pyridines, and pyrido[2,3-d]pyrimidines) was generated by Combes-type reaction of acyl pyruvates and electron-rich amino heterocycles followed by hydrolysis of the ester. The library members were also demonstrated to undergo the standard combinatorial transformations including amide coupling and esterification, as well as less common heterocyclizations to 1,2,4-triazoles and 1,2,4-oxadiazoles.

TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R1, R2 and R3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.