35244-52-1

Upstream product

• 123-75-1 pyrrolidine 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 

Downstream Products

• 869319-32-4 ethyl [2-oxo-3-(2-oxo-2-phenylethyl)cyclohexyl]acetate 
• 869319-38-0 ethyl (2-oxo-3-prop-2-yn-1-yl-cyclohexyl)acetate 
• 24731-17-7 ethyl 2-(2-oxocyclohexyl)acetate 
• 869320-05-8 ethyl [3-(2,4-dichlorobenzoyl)-2-oxocyclohexyl]acetate 
• 869319-40-4 ethyl {3-[(2E)-but-2-en-1-yl]-2-oxocyclohexyl}acetate 

Relevant academic research and scientific papers

(4, 5, 6, 7-TETRAHYDRO-1-H-INDOL-7-YL) ACETIC ACID DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE

Compounds of formula: (I); are disclosed. The compounds are useful in treating or preventing diseases associated with deposition of Aβ in the brain.

The γ-alkylation of cyclic β-ketoesters via their enamine derivatives

The γ-alkylation - functionalization of cyclic β-ketoesters via their enamine derivatives is discussed with particular emphasis on their preparation from β-ketoesters and their reaction with various electrophiles such as electrophilic olefins, halogenoids, anmd allylic and benzylic halides.Although the amine ring size does not appear to affect reactivity to a great extent, the reaction is very sensitive to β-ketoester ring size, with six-membered rings giving the best results.In the latter case the alkylation-functionalization is general and specific to the γ-position and therefore provides an important complement to the dianion and related methodologies.