3525-80-2Relevant academic research and scientific papers
Introducing a longer versus shorter acylhydrazone linker to a metal-organic framework: Parallel mechanochemical approach, nonisoreticular structures, and diverse properties
Roztocki, Kornel,Szufla, Monika,Hodorowicz, Maciej,Senkovska, Irena,Kaskel, Stefan,Matoga, Dariusz
, p. 7160 - 7169 (2019)
A 20-?-long diacylhydrazone linker was used for the first time as a building block for the construction of a metal-organic framework (MOF). The terephthalaldehyde di-isonicotinoylhydrazone (tdih) is considerably longer than its 11-?-long monoacylhydrazone
Synthesis and antitubercular activities in Vitro of new p-aminosalicylic ester imines
Hearn, Michael J.,Smaltz, Daniel J.,Cynamon, Michael H.
, p. 953 - 959 (2014/10/15)
In the present study, novel imines (5-16) of para-aminosalicylic esters were prepared in good yield and purity for the investigation of their antimycobacterial properties in vitro. The chemical structures of the compounds were determined by IR, 1H-NMR, 13C-NMR, high resolution mass spectrometry and elemental analysis. Unlike para-aminosalicylic acid itself, these compounds are thermally stable and displayed activity in two models using pathogenic strains of Mycobacterium tuberculosis. Compound 5, bearing an ortho-hydroxybenzylidene unit, demonstrated promising activity in vitro and a range of cytotoxic and inhibitory properties that warrant further studies.
Preparation and antitubercular activities in vitro and in vivo of novel Schiff bases of isoniazid
Hearn, Michael J.,Cynamon, Michael H.,Chen, Michaeline F.,Coppins, Rebecca,Davis, Jessica,Joo-On Kang, Helen,Noble, Abigail,Tu-Sekine, Becky,Terrot, Marianne S.,Trombino, Daniella,Thai, Minh,Webster, Eleanor R.,Wilson, Rebecca
experimental part, p. 4169 - 4178 (2009/12/04)
Structural modification of the frontline antitubercular isonicotinic acid hydrazide (INH) provides lipophilic adaptations (3-46) of the drug in which the hydrazine moiety of the parent compound has been chemically blocked from the deactivating process of N2-acetylation by N-arylaminoacetyl transferases. As a class, these compounds show high levels of activity against Mycobacterium tuberculosis in vitro and in tuberculosis-infected macrophages. They provide strong protection in tuberculosis-infected mice and have low toxicity. With some representatives of this class achieving early peak plasma concentrations approximately three orders of magnitude above minimum inhibitory concentration, they may serve as tools for improving our understanding of INH-based treatment modalities, particularly for those patients chronically underdosed in conventional INH therapy.
Polymeric Bipositive Metal Ion Complexes of Terephthalaldehyde bis-(isonicotinic acid hydrazone)
Singh, Bhagwat,Maurya, P. L.,Agarwala, B. V.,Dey, Arun K.
, p. 29 - 31 (2007/10/02)
Terephthalaldehyde bis-(isonicotinic acid hydrazone) (TBINH) has been synthesized by the condensation of terephthalaldehyde and isonicotinic acid hydrazide.TBINH yields complexes, n -, NO3- and x=0, 1 or 2>, on refluxing a mixture of TBINH and metal salt in DMF medium in 1:1 ratio.Infrared and reflectance spectra, magnetic and thermogravimetric studies indicate that the complexes are polymeric having octahedral geometry.The order of thermal stability of the polymers is: Zn > Cd > Co > Mn > UO2 > Ni.
Synthesis and Characterization of Copper(II)-Terephthalaldehyde bis-(isonicotinic Acid Hydrazone)
Singh, Bhagwat,Maurya, P. L.,Agarwala, B. V.,Dey, Arun K.
, p. 541 - 543 (2007/10/02)
Terephthalaldehyde bis-(isonicotinic acid hydrazone) formed by the condensation of terephthalaldehyde and isonicotinic acid hydrazide), yields polymeric complexes, CuL*X2*xH2O where L=C20H16N6O2, X=CH2COO(1-)( (a), Cl(1-) (b), Br(1-) (c), NO3(1-) (d), 1/
