35250-01-2Relevant academic research and scientific papers
GLUCAGON RECEPTOR MODULATORS
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Page/Page column 18, (2012/08/27)
The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, A1, A2, A3, A4, L, B1, B2, B3 and B4 are as defined herein. The compounds of Formula I have been found to act as glucagon antagonists or inverse agonists. Consequently, the compounds of Formula I and the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucagon.
N-Arylation of 4-fluoro-5-trimethylsilyl-1H-pyrazole
Hanamoto, Takeshi,Iwamoto, Yuhko,Yamada, Kenji,Anno, Ryoko
, p. 1126 - 1130 (2008/02/10)
The 1,3-dipolar cycloaddition reaction of fluoro(trimethylsilyl)acetylene prepared in situ with an excess of diazomethane smoothly proceeded to give the corresponding 4-fluoro-5-trimethylsilyl-1H-pyrazole in 84% yield. The copper iodide-catalyzed N-arylation of the fluorinated pyrazole with a variety of aryl iodides afforded N-aryl-4-fluoropyrazoles as desilylation products in good to excellent yields.
