35252-03-0

Usage

Uses

Used in Pharmaceutical Industry:
Pyrido[2,3-b]pyrazin-2(1H)-one is used as a pharmaceutical intermediate for the development of various drugs. Its unique structure allows it to be a key component in the synthesis of medicinal compounds, potentially leading to new treatments and therapies.
Used in Chemical Synthesis:
In the field of chemical synthesis, Pyrido[2,3-b]pyrazin-2(1H)-one serves as a building block for creating more complex organic molecules. Its ability to be incorporated into larger structures makes it a valuable asset in the design and creation of novel chemical entities.
Used in Antioxidant Applications:
Pyrido[2,3-b]pyrazin-2(1H)-one is utilized as an antioxidant, which can help protect cells from damage caused by reactive oxygen species. Its potential use in this area could contribute to the development of health supplements or pharmaceuticals aimed at reducing oxidative stress.
Used in Anti-Inflammatory Applications:
As an anti-inflammatory agent, Pyrido[2,3-b]pyrazin-2(1H)-one may be employed in the development of treatments for conditions characterized by inflammation. Its potential in this area could lead to new therapeutic options for managing inflammation-related disorders.

Upstream product

• 25710-18-3 2,3-Dichloro-pyrido[2,3-b]pyrazine 
• 934993-79-0 2-chloro-3-hydrazinylpyrido[2,3-b]pyrazine 
• 452-58-4 2,3-Diaminopyridine 
• 924-44-7 glyoxylic acid ethyl ester 
• 563-96-2 2,2-dihydroxyacetic acid 

Downstream Products

• 70838-55-0 2-chloropyrido[2,3-b]pyrazine 

Relevant academic research and scientific papers

INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS

Provided herein are compounds of formula (V) that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease.

Rationalization of benzazole-2-carboxylate versus benzazine-3-one/ benzazine-2,3-dione selectivity switch during cyclocondensation of 2-aminothiophenols/phenols/anilines with 1,2-biselectrophiles in aqueous medium

The cyclocondensation reaction of 2-aminothiophenols with 1,2-biselectrophiles such as ethyl glyoxalate and diethyl oxalate in aqueous medium leads to the formation of benzothiazole-2-carboxylates via the 5-endo-trig process contrary to Baldwin's rule. On the other hand, the reaction of 2-aminophenols/anilines produced the corresponding benzazine-3-ones or benzazine-2,3-diones via the 6-exo-trig process in compliance with Baldwin's rule. The mechanistic insights of these cyclocondensation reactions using the hard-soft acid-base principle, quantum chemical calculations (density functional theory), and orbital interaction studies rationalize the selectivity switch of benzothiazole-2-carboxylates versus benzazine-3-ones/ benzazine-2,3-diones. The presence of water facilitates these cyclocondensation reactions by lowering of the energy barrier.

NOVEL HETEROCYCLIC COMPOUND OR SALT THEREOF AND INTERMEDIATE THEREOF

Disclosed is a compound represented by the general formula: [wherein R1 represents an aryl or heterocyclic group which may be substituted or the like; X1 represents a C2-C4 alkylene group or the like; X2, X3 and X5 independently represent NH, a bond or the like; X4 represents a lower alkylene group, a bond or the like; Y1 represents a bivalent alicyclic hydrocarbon residue which may be substituted or a bivalent alicyclic amine residue which may be substituted; and Z1, Z2, Z3, Z4, Z5 and Z6 independently represent a nitrogen atom, a group represented by the formula: CH, or the like, provided that at least one of Z3, Z4, Z5 and Z6 represents a nitrogen atom] or a salt thereof, which is useful as an antibacterial agent.

Reduction of different electron-poor N-heteroarylhydrazines in strong basic conditions

The first application of the Wolff-Kishner reduction methodology to electron-poor heteroaromatic compounds is reported. Hydrazino-containing heterocycles with hydrazone-type tautomery have been reduced under basic conditions. This novel chemistry was successfully applied to mono-dehalogenate a number of electron-poor heterocycles in a regioselective manner. According to the experimental results, this reductive process is a base-catalyzed reaction that takes only place in the presence of air, probably through an oxygen-assisted mechanism. As consequence of the specific features of this kind of hydrazone/enehydrazine tautomers, the overall outcome of the process is the synthesis of a Shapirotype reduction product by simply using a milder version of the Huang-Minlon methodology.

Comparative Kinetic Studies on the Synthesis of Quinoxalinone Derivatives and Pyridopyrazinone Derivatives by the Hinsberg Reaction

Kinetic studies on the anelation of quinoxalinone derivatives 3a-c and pyridopyrazinone derivatives 5a-c and 6a-c synthesized by the Hinsberg reaction is reported. o-Phenylenediamine or 2,3-diaminopyridine were treated with bifunctional carbonyl compounds such as glyoxylic, pyruvic and benzoylformic acids under different experimental conditions.When pyridopyrazine derivatives were synthesized both position isomers were achieved applying regioselective reactions.Mixture were avoided by looking for special experimental conditions that led unambigously to only one of the components of the classic "Hinsberg mixture".Quinoxalinone derivatives 3a-c were obtained at room temperature in good yields (>90percent) using anhydrous methanol or ethanol as solvents.On the other hand, only pyridopyrazin-3(4H)-one (5a) was regioselectively attained in aqueous buffer of pH 7 while 3-methylpyridopyrazinone derivatives were regioselectively separated using anhydrous methanol for one isomer, 5b, and anhydrous chloroform for the other isomer, 6b, at room temperature.Yields were higher than 80percent.Reactions with benzoylformic acid did not give good yields and only 2-phenylpyridopyrazin-3(4H)-one (5c) could be obtained using anhydrous chloroform (yield pyrazin-3(4H)-one (5c) in good yields applying this technique.The other isomer, 3-phenylpyrazin-2(1H)-one (6c) was always formed together with the former isomer and could not be isolated from the mixture, when other solvents than chloroform were used as the reaction media.