352554-07-5

Upstream product

• 13820-19-4 (1-phenylamino)ethylidene-propanedinitrile 
• 96-32-2 bromoacetic acid methyl ester 
• 109-77-3 malononitrile 
• 62-53-3 aniline 
• 91255-14-0 α-Cyano-β-N-phenylaminocrotonamide 
• 62321-92-0 α-cyano-β-dimethylaminocrotonamide 

Downstream Products

• 383161-28-2 6-methyl-4-oxo-5-phenyl-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidine-7-carbonitrile 
• 360062-30-2 4-cyano-3-dimethylaminomethinamino-2-methoxycarbonyl-5-methyl-1-phenylpyrrole 

Relevant academic research and scientific papers

One-pot synthesis of pentasubstituted pyrroles from tertiary amides and malononitrile via an indirect condensation reaction on amidic carbonyl group

An one-pot procedure for the preparation of pentasubstituted pyrrole derivatives, using tertiary acid amides-phosphorus oxychloride adducts on reaction with malononitrile, in the presence of triethylamine, is described.

Torp-Ziegler cyclization in the synthesis of 3-amino-4-cyanopyrrole derivatives

Polyfunctional derivatives of 3-aminopyrrole have been synthesized from several substituted β-enamino nitriles using Torp-Ziegler cyclization. These compounds are starting materials for further conversions, particularly for the synthesis of pyrrolo[3,2-d]