35258-88-9Relevant academic research and scientific papers
Regioselective synthesis of substituted isoxazolo[5,4-d]pyrimidines
Alyabiev, Sergey B.,Kravchenko, Dmitri V.,Ivachtchenko, Alexandre V.
, p. 144 - 146 (2008/09/21)
A convenient regioselective synthesis of new N- and O-substituted isoxazolo[5,4-d]pyrimidine derivatives is described.
N-ARYL-ISOXAZOLOPYRIMIDIN-4-AMINES AND RELATED COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF
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Page/Page column 52-53, (2008/12/05)
Disclosed are N-aryl-isoxazolopyrimidin-4-amines and related compounds thereof, represented by the Formula (I): wherein Ar, R1-R5, A, B, D, E, F and H are defined herein. The present invention relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
Synthesis of fused pyrimidinones by reaction of aminoarene-carboxamide with esters; Preparation of pyrrolo[2,3-d]-, thieno[2,3-d]-, isoxazolo[5,4-d]- and 1,2,3-triazolo[4,5-d]pyrimidinones, and quinazolones
Miyashita, Akira,Fujimoto, Katsuhiro,Okada, Tomomi,Higashino, Takeo
, p. 691 - 699 (2007/10/03)
Several fused pyrimidinones were synthesized by reaction of aminoarenecarboxamide with esters in moderate to good yields. In the presence of sodium ethoxide, treatments of 2-amino-l-phenyl-3-pyrrolecarboxamide(4, 5, and 6), 2-amino-3-thiophenecarboxamide (14), 3-amino-4-isoxazolecarboxamide (10 and 11), 4-amino-1,2,3-triazole-5-carboxamide (16), and o-aminobenzamide (18) with esters (3) such as ethyl formate (3a) and ethyl acetate (3b) led to the corresponding pyrrolo[2,3-d]- (7, 8, and 9), and thieno[2,3-d]pyrimidin-4(3H)-ones (15), isoxazolo[5,4-d]pyrimidin-4(5H)-ones (12 and 13), 1,2,3-triazolo[4,5-d]pyrimidin-7(6H)-ones (17), and 4(3H)-quinazolones (19), respectively.
Pesticidal compounds, compositions and processes
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, (2008/06/13)
A process for combating pests, especially fungi, which comprises applying to plants, seeds, or their loci, an isoxazolo [5,4-d] pyrimidine derivative having the formula: STR1 or a salt or optical isomer thereof, wherein R is alkyl or aralkyl, either optionally-substituted; R2 is hydrogen or alkyl; R3 is alkyl, aryl, alkylthio, alkanesulphonyl, alkoxy, aryloxy, cyano or optionally-substituted amino.
