352662-87-4Relevant academic research and scientific papers
Aromatic 2-(thio)ureidocarboxylic acids as a new family of modulators of multidrug resistance-associated protein 1: Synthesis, biological evaluation, and structure - Activity relationships
H?cker, Hans-Georg,Leyers, Stefan,Wiendlocha, Jeanette,Gütschow, Michael,Wiese, Michael
supporting information; experimental part, p. 4586 - 4595 (2010/03/03)
Four series of aromatic carboxylic acids were prepared with a urea or thiourea moiety at the neighboring position to the carboxyl group and benzene or thiophene as aromatic scaffold. Using a calcein AM assay, these compounds were evaluated as inhibitors o
Inhibition of human chymase by 2-amino-3,1-benzoxazin-4-ones
Neumann, Ulf,Schechter, Norman M.,Guetschow, Michael
, p. 947 - 954 (2007/10/03)
A series of 2-sec.amino-4H-3,1-benzoxazin-4-ones was evaluated as acyl-enzyme inhibitors of human recombinant chymase. The compounds were also assayed for inhibition of human cathepsin G, bovine chymotrypsin, and human leukocyte elastase. Introduction of
