79860-08-5Relevant academic research and scientific papers
Inhibition of human chymase by 2-amino-3,1-benzoxazin-4-ones
Neumann, Ulf,Schechter, Norman M.,Guetschow, Michael
, p. 947 - 954 (2001)
A series of 2-sec.amino-4H-3,1-benzoxazin-4-ones was evaluated as acyl-enzyme inhibitors of human recombinant chymase. The compounds were also assayed for inhibition of human cathepsin G, bovine chymotrypsin, and human leukocyte elastase. Introduction of
HETEROCYCLIZATION WITH IMINIUM CHLORIDES, II. SYNTHESIS OF 4H--BENZOXAZINE-4-ONES AND QUINAZOLINONES
Bitter, I.,Szoecs, L.,Toeke, L.
, p. 57 - 66 (2007/10/02)
Reactions between methyl anthranilate and a variety of PI salts afforded 2-ammonio-4H--benzoxazine-4-one chlorides which were subjected to nucleophilic reactions.With primary amines, 2-ureidoanthraniloyl amides were obtained, which were smoothly cyclized in boiling acetic anhydride or dimethylformamide to give 1H,3H-quinazoline-2,4-diones.
