352665-53-3Relevant academic research and scientific papers
Design and synthesis of 2-oxo-imidazolidine-4-carboxylic acid hydroxyamides as potent matrix metalloproteinase-13 inhibitors
Robinson, Ralph P.,Laird, Ellen R.,Donahue, Kathleen M.,Lopresti-Morrow, Lori L.,Mitchell, Peter G.,Reese, Matthew R.,Reeves, Lisa M.,Rouch, Amber I.,Stam, Ethan J.,Yocum, Sue A.
, p. 1211 - 1213 (2001)
A novel series of imidazolidinone-based matrix metalloproteinase (MMP) inhibitors was discovered by structural modification of pyrrolidinone 1a. Potent inhibition of MMP-13 was exhibited by the analogues having 4-(4-fluorophenoxy)phenyl (4a, IC50/su
