Bioorganic and Medicinal Chemistry Letters p. 1211 - 1213 (2001)
Update date:2022-09-26
Topics:
Robinson, Ralph P.
Laird, Ellen R.
Donahue, Kathleen M.
Lopresti-Morrow, Lori L.
Mitchell, Peter G.
Reese, Matthew R.
Reeves, Lisa M.
Rouch, Amber I.
Stam, Ethan J.
Yocum, Sue A.
A novel series of imidazolidinone-based matrix metalloproteinase (MMP) inhibitors was discovered by structural modification of pyrrolidinone 1a. Potent inhibition of MMP-13 was exhibited by the analogues having 4-(4-fluorophenoxy)phenyl (4a, IC50 View More
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