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352708-55-5

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352708-55-5 Usage

General Description

(3-iodophenyl)methanesulfonyl chloride, also known as IPMSCl, is a chemical compound with the formula C7H6ClIO2S. It is a sulfonyl chloride derivative with a substituent of iodine attached to a phenyl ring. IPMSCl is commonly used as a reagent in organic synthesis, particularly in the preparation of sulfonamides and other organic compounds. It is known for its ability to selectively introduce the sulfonyl chloride group to various organic molecules, making it a versatile tool in the field of organic chemistry. Additionally, it is known for its role in medicinal chemistry and drug discovery, where it is utilized in the synthesis of pharmaceutical compounds. However, it is important to handle this chemical with caution, as it is a strong irritant to the skin, eyes, and respiratory system, and should be used in a well-ventilated area with appropriate protective equipment.

Check Digit Verification of cas no

The CAS Registry Mumber 352708-55-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,2,7,0 and 8 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 352708-55:
(8*3)+(7*5)+(6*2)+(5*7)+(4*0)+(3*8)+(2*5)+(1*5)=145
145 % 10 = 5
So 352708-55-5 is a valid CAS Registry Number.

352708-55-5Downstream Products

352708-55-5Relevant articles and documents

Synthesis and receptor binding studies of novel 4,4-disubstituted arylalkyl/arylalkylsulfonyl piperazine and piperidine-based derivatives as a new class of σ1 ligands

Sadeghzadeh, Masoud,Sheibani, Shahab,Ghandi, Mehdi,Daha, Fariba Johari,Amanlou, Massoud,Arjmand, Mohammad,Hasani Bozcheloie, Abolfazl

, p. 488 - 497 (2013/07/27)

This study presents the synthesis and biological evaluation of a new series of arylalkyl/arylalkylsulfonyl piperazine and piperidine-based derivatives as sigma receptor ligands. It was found that a number of halogen substituted sulfonamides display relatively high and low affinities to σ1 and σ2 receptors, respectively. The σ1 affinities and subtype selectivities of four piperidine derivatives were also found to be generally comparable to those of piperazine analogues. Compared to σ1-Rs compounds with n = 0 and 2, those with n = 1 proved to have optimal length of carbon chain by exhibiting higher affinities. Within this series, the 4-benzyl-1-(3-iodobenzylsulfonyl)piperidine sigma ligand was identified with 96-fold σ1/σ2 selectivity ratio (Kiσ1 = 0.96 ± 0.05 nM and K iσ2 = 91.8 ± 8.1 nM).

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