35278-62-7

Upstream product

• 35256-82-7 (p-chlorophenyl)(m-methylphenyl)methanone 
• 1711-06-4 3-Methylbenzoyl chloride 
• 94-36-0 dibenzoyl peroxide 
• 99-04-7 m-Toluic acid 

Downstream Products

• 99519-96-7 3-(4-chlorobenzoyl)benzyl azide 
• 35256-83-8 3-p-chlorobenzoyl phenyl acetonitrile 
• 183165-31-3 1-[3-(4-Chlorobenzoyl)benzyl]-2,3-dichloro-5-methyl-1H-pyrrolo [2,3-d]pyridazin-4(5H)-one 
• 183165-36-8 1-[3-(4-Chlorobenzoyl)benzyl]-5-methyl-1H-pyrrolo-[2,3-d]pyridazin-4(5H)-one 
• 183164-95-6 2-[3-(4-Chlorobenzoyl)benzylthio]-3,5-dimethyl-quinazolin-4-one 
• 24031-42-3 3-(4-chlorobenzoyl)-benzeneacetic acid 
• 55142-60-4 2-[3-(4-Chloro-benzoyl)-phenyl]-N-hydroxy-acetamide 
• 35256-78-1 methyl 3-p-chlorobenzoyl phenylacetate 
• 99519-82-1 5-Amino-1-(3-[4-chlorobenzoyl]benzyl)-1,2,3-triazole-4-carboxamide 

Relevant academic research and scientific papers

Benzylated 1,2,3-triazoles as anticoccidiostats

Substituted 5-amino-4-carbamoyl-1,2,3-triazoles 3a-w were prepared by two synthetic schemes and evaluated in vivo for anticoccidial activity. Both schemes proceeded by brominating appropriately substituted toluenes 4a-s,v to 5a-s,v. In Scheme I, the brominated benzyl analogues 5 were converted to the corresponding benzyl azides 6, which were treated with cyanoacetamide to yield 1-substituted-5-amino-4-carbamoyl-1,2,3-triazoles 3. In Scheme II, the benzyl halides 5 were employed to alkylate the sodium salt of 5-amino-4-carbamoyl-1,2,3-triazole (7). Preliminary screening data against Eimeria acervulina and E. tenella in chickens suggested structural requirements for maximizing activity. Further evaluation against a relatively resistant series of eight Eimeria field isolates revealed L-651,582 (3a) to be a highly effective coccidiostat. However, unacceptable tissue residues precluded further development. Mechanistic studies on this series of 5-amino-4-carbamoyl-1,2,3-triazoles and, in particular, on L-651,582 (3a) revealed that its mode of action does not involve inhibition of IMP dehydrogenase, but probably interferes with host cell calcium entry. In addition, L-651,582 has been found to have antiproliferative activity in several disease models and was recently reported to possess antimetastatic activity in a model of ovarian cancer progression.

5-amino or substituted amino 1,2,3-triazoles

Novel 5-amino or substituted amino 1,2,3-triazoles are disclosed as having anticoccidial activity. The compounds are useful for controlling coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with a

Novel benzoylphenylacetic acid esters

Racemates [and optically active isomers of benzoylphenylacetic acid esters of the formula STR1 wherein R is selected from the group consisting of hydrogen and alkyl of 1 to 7 carbon atoms, and the two benzene rings may be optionally substituted with at le

Benzoylphenylacetic acid derivatives with antiinflammatory and analgesic activities

Several derivatives of m benzoylphenylacetic acid showed interesting antiinflammatory and analgesic properties associated with good gastric tolerance.