35278-83-2Relevant academic research and scientific papers
Method for synthesizing homoallylamine compounds
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Paragraph 0024-0027; 0036-0039, (2020/05/01)
The invention discloses a method for synthesizing homoallylamine compounds, and belongs to the field of organic synthesis. N,N-acetal compounds represented by formula (I) are used as a substrate, andreact with a nucleophilic reagent allyl silicon compound represented by formula (II) under the activation of a Lewis acid to efficiently prepare the homoallylamine compounds represented by formula (III), and the yield can reach 85%. The method is simple and green, can efficiently obtain the target product, and has very good industrial application prospects.
Copper-Catalyzed Regioselective Ring-Opening Hydroamination of Methylenecyclopropanes
Nishikawa, Daiki,Sakae, Ryosuke,Miki, Yuya,Hirano, Koji,Miura, Masahiro
, p. 12128 - 12134 (2016/12/23)
A copper-catalyzed ring-opening hydroamination of methylenecyclopropanes with polymethylhydrosiloxane and O-benzoylhydroxylamines has been developed. The cyclopropane C-C bond cleavage occurs selectively at the more congested proximal position, and the corresponding homoallylamines are obtained in good to excellent yields. The umpolung electrophilic amination strategy with the hydroxylamine derivatives can provide a new reaction mode of methylenecyclopropanes in the catalytic hydroamination reaction.
Allylation of n,n-acetal derivatives using allyl tin reagent in the presence of aluminum chloride
Sun, Xiaonan,Obu, Takanori,Kijima, Tatsuro,Murakami, Satoshi,Matsuba, Shigeru,Kusakari, Miho,Hatano, Bunpei
, p. 2395 - 2402 (2013/11/19)
Allylation of N,N-acetal derivatives proceeded efficiently using allyl tin regent in the presence of aluminum chloride, giving homoallylamines in good yields. This allylation was applied for N,S-acetals to give the corresponding homoallylamines.
Zinc-mediated allylation and alkylation of aminals in the presence of TMSCl and diisopropylamine
Hatano, Bunpei,Nagahashi, Keita,Kijima, Tatsuro
supporting information; experimental part, p. 9188 - 9191 (2009/04/11)
(Chemical Equation Presented) An alkylation of aminals with organozinc reagents derived from allyl bromide, benzyl bromide, α-bromoacetate, and α-bromonitrile proceeded efficiently in the presence of TMSCl and diisopropylamine. This reaction system was applied to the synthesis of an antispasmodic: butaverine.
