35289-35-1Relevant academic research and scientific papers
Copper-catalyzed enantioselective conjugate addition of Grignard reagents to α,β-unsaturated esters
Lopez, Fernando,Harutyunyan, Syuzanna R.,Meetsma, Auke,Minnaard, Adriaan J.,Feringa, Ben L.
, p. 2752 - 2756 (2005)
(Chemical Equation Presented) Stable dinuclear Cu complexes have been used to catalyze the conjugate addition of inexpensive and readily available Grignard reagents to acyclic α,β-unsaturated esters. The method provides the correspending β-substituted optically active esters in high yields and with excellent enantioselectivities (see scheme). R3 = cyclohexyl, R 4 = Ph or R3 = Ph, R4 = cyclohexyl.
