353-81-1

Usage

Uses

Used in Refrigeration Industry:
2,2-difluorobutane is utilized as a refrigerant due to its thermodynamic properties that make it suitable for cooling applications. Its performance as a refrigerant is attributed to its ability to absorb and release heat effectively.
Used as a Propellant in Aerosol Sprays:
In the consumer goods industry, 2,2-difluorobutane serves as a propellant in aerosol sprays, providing the force necessary to dispense products such as personal care products, cleaning agents, and other spray formulations.
Used in Pharmaceutical Production:
2,2-difluorobutane is employed as an intermediate in the synthesis of various pharmaceuticals. Its unique chemical properties allow it to participate in reactions that produce medicinally relevant compounds.
Used in Agrochemical Production:
Similarly, in the agrochemical sector, 2,2-difluorobutane is used in the manufacturing process of certain pesticides and other agricultural chemicals, contributing to the development of effective products for crop protection.
However, it is crucial to handle 2,2-difluorobutane with care due to its potential environmental impact. As a compound with a high global warming potential, it is classified as a significant greenhouse gas, and its release into the atmosphere should be minimized to mitigate its contribution to climate change.

InChI:InChI=1/C4H8F2/c1-3-4(2,5)6/h3H2,1-2H3

Upstream product

• 4461-41-0 2-chloro-but-2-ene 
• 2211-70-3 2-chloro-but-1-ene 
• 420-96-2 2-chloro-2-fluoro-butane 
• 4279-22-5 2,2-dichlorobutane 
• 373-90-0 3,3-difluoro-1-butene 
• 78-93-3 butanone 
• 66675-39-6 (E)-2-fluoro-2-butene 
• 107-00-6 but-1-yne 
• 7664-39-3 hydrogen fluoride 
• 503-17-3 dimethylacetylene 
• 7783-56-4 antimony(III) fluoride 
• 513-38-2 Isobutyl iodide 
• 624-64-6 trans-2-Butene 

Downstream Products

• 7664-39-3 hydrogen fluoride 

Relevant academic research and scientific papers

Hydrofluorination of Unsaturated Compounds with Solid Potassium Hydrogen Fluoride in the Presence of Silicon Tetrafluoride at Room Temperature

Hydrofluorination of unsaturated compounds proceeds by reaction with solid potassium hydrogen fluoride and silicon tetrafluoride to afford the corresponding fluorides in high yields.

Rearrangement and double fluorination in the deiodinative fluorination of neopentyl iodide with xenon difluoride

Alkyl iodides give products from the neopentyl rearrangement on reaction with xenon difluoride. Neopentyl iodide performs a double rearrangement and yields a gem-difluoro product, 2,2-difluoro-3-methylbutane. Studies of the mechanism show that an alkene intermediate is involved in the double rearrangement process. Alkenes can be substituted as substrates in reaction with xenon difluoride-iodine to give gem-difluoro products. 13C Labeling verifies the skeletal rearrangement process.

Method of Synthesis of Arylsulfur Trifluorides and Use as in situ Deoxofluorination Reagent

The invention is a method of synthesizing Arylsulfur Trifluorides, such as Fluolead, by reacting BR2 and KF (or suitable alkali metal fluoride) in acetonitrile (or other suitable solvent). The invention also comprises using the Fluolead (or its

Arylsulfur trifluorides: Improved method of synthesis and use as in situ deoxofluorination reagents

Building on recent results of Umemoto and Winter, an improved method of synthesis of arylsulfur trifluorides, including the excellent, new deoxofluorination reagent Fluolead, is hereby reported. The method utilizes Br2 and KF as oxidizing and fluorinating reagents for efficient, high yield conversion of aryl disulfides and mercaptans to arylsulfur trifluorides. It has also been shown that both Fluolead and mesitylsulfur trifluoride may be generated in acetonitrile and used as in situ deoxofluorination reagents for conversion of either aldehydes or ketones to their respective gem-difluoro compounds. An analysis of the probable mechanism of action, including computational efforts, allows postulation of a rationale for the highly variable reactivities of different arylsulfur trifluorides as deoxofluorination reagents.

vic-difluorination of fluoroalkenes with xenon difiuoride: The effect of fluorine substituents on the reaction of alkenes with xenon difluoride

vic-Difluorination proceeds by the reaction of fluoroalkenes with xenon difluoride to afford the corresponding fluorinated compounds. From the reaction with polyfluoroalkenes, the products are obtained in high to excellent yields. In this reaction, the fluorine atom substituent of alkene stabilizes the cation intermediate and suppresses side-reactions such as rearrangement.

Transformation of Carbonyl Compounds into gem-Difluoro Compounds with Dibromodifluoromethane/Zinc Reagent

Reaction of carbonyl compounds with dibromodifluoromethane/zinc gives the gem-difluoro compounds (12 examples).It seems to be that the reaction involves the generation of difluorocarbene by reaction of dibromodifluoromethane with zinc, followed by product

REACTIONS OF ALIPHATIC KETONES WITH SULFUR TETRAFLUORIDE AND HF IN THE PRESENCE OF SULFUR MONOCHLORIDE

Aliphatic ketones react with SF4 and anhydrous hydrogen fluoride in the presence of catalytic amounts of S2Cl2 to give polyfluorinated sulfides and disulfides.The reactions occur via intermediate alkene derivatives.