35306-52-6

Usage

Uses

Used in Pharmaceutical Industry:
N-ALLYL-3-CHLOROBENZENECARBOXAMIDE is used as a key intermediate in the synthesis of various drugs and pharmaceutical products, contributing to the development of new medications and therapies.
Used in Organic Chemistry:
In the field of organic chemistry, N-ALLYL-3-CHLOROBENZENECARBOXAMIDE serves as a reagent or intermediate for the production of other organic compounds, facilitating the synthesis of a wide range of chemical products.

InChI:InChI=1/C10H10ClNO/c1-2-6-12-10(13)8-4-3-5-9(11)7-8/h2-5,7H,1,6H2,(H,12,13)

Upstream product

• 107-11-9 1-amino-2-propene 
• 535-80-8 3-chlorobenzoate 
• 618-46-2 m-Chlorobenzoyl chloride 

Downstream Products

• 35306-50-4 3-chloro-N-propylbenzamide 
• 1433416-61-5 (2-(3-chlorophenyl)-4,5-dihydrooxazol-5-yl)methyl acetate 
• 1395225-00-9 5-(bromomethyl)-2-(3-chlorophenyl)oxazole 
• 66896-84-2 N-Allyl-N-(3-chloro-benzoyl)-benzenesulfonamide 

Relevant academic research and scientific papers

Electrochemical Fluorocyclization of N-Allylcarboxamides to 2-Oxazolines by Hypervalent Iodine Mediator

A resource saving protocol for the synthesis of 5-fluoromethyl-2-oxazolines by using electrochemistry has been realized. Thereby, a hypervalent iodine species I(III) is generated by anodic oxidation in the presence of Et3N·5HF and mediates the

Electrochemical oxidative cyclization of olefinic carbonyls with diselenides

The tandem cyclization of olefinic carbonyls with easily accessible diselenides facilitated by electrochemical oxidation has been successfully developed, which provides an environmentally friendly method for the construction of C-Se and C-O bonds simultaneously. A series of seleno dihydrofurans and seleno oxazolines, bearing fragile heterocycles, subtle C-I bonds and supernumerary vinyl groups, were forged using this elegant chelation strategy. Neither metal catalysts nor external chemical oxidants are required to promote this transformation.

Iodine(III)-promoted synthesis of oxazolines from N-allylamides

PhI(OAc)2 (activated by BF3·OEt2) has been used to promote the oxidative cyclization of N-allylamides to give oxazolines. The reaction products are formed in high yield and, when a branched allylic amine is used, high diastereoselectivity. Initial mechanistic experiments suggest that the final C-O bond is formed from a reactive tight ion pair, rather than a neutral external nucleophile.

POTENTIAL CENTRAL NERVOUS SYSTEM ACTIVE AGENTS. 3. SYNTHESIS OF SOME SUBSTITUTED BENZAMIDES AND PHENYLACETAMIDES.

The preparation and special properties (IR, **1H NMR) are given for 45 benzamides and 10 phenylacetamides substituted on nitrogen with allyl, benzhydryl, benzyl, or cyclopropyl groups, and variously substituted on the acyl part with halo, methoxyl, methyl, or nitro groups. The benzamide derivatives were synthesized by the Schotten-Baumann method, and the phenylacetamide derivatives were prepared by heating the appropriate N-benzhydrylammonium salt in o-xylene. Thirty-one of the compounds are new.