35306-53-7

Upstream product

• 93535-10-5 (3-Chloro-phenyl)-carbamic acid p-tolyl ester 
• 109-73-9 N-butylamine 
• 102736-21-0 (3-Chloro-phenyl)-carbamic acid 4-chloro-phenyl ester 
• 201230-82-2 carbon monoxide 
• 625-99-0 3-iodochlorobenzene 
• 873-63-2 m-chlorobenzyl alcohol 
• 108-41-8 1-chloro-3-methylbenzene 
• 618-46-2 m-Chlorobenzoyl chloride 

Relevant academic research and scientific papers

Towards a sustainable synthesis of amides: chemoselective palladium-catalysed aminocarbonylation of aryl iodides in deep eutectic solvents

A palladium-catalysed aminocarbonylation of (hetero)aryl iodides has, for the first time, been accomplished in deep eutectic solvents as environmentally benign and recyclable media, under mild conditions. The reactions proceeded with a good substrate scope, and a variety of amides have been synthesized in yields up to 98%.

Radical-mediated divergent cyclization of benzamides toward perfluorinated or cyanated isoquinolinediones

A simple and efficient copper-controlled divergent cyclization of benzamides, which leads to perfluorinated or cyanated isoquinolinediones, is developed. In the presence of AIBN, methacryloyl benzamides with perfluoroalkyl iodides undergo cascade radical addition/cyclization to afford perfluoroinated isoquinolinediones as the major product under metal-free conditions, whereas the use of CuI (10 mol%) is able to redirect the cyclization to yield isoquinolinediones bearing an α-cyano quaternary carbon center. The cyclization features controllable divergent synthesis and a broad substrate scope as well as highly practical reaction conditions, thereby making this strategy a highly attractive means to fluorinate or cyanate isoquinolinediones.

Direct oxidative amidation between methylarenes and amines in water

An environmentally friendly direct oxidative amidation between methylarenes and free amines was developed. The aromatic amide could be prepared efficiently from raw chemicals by employing TBHP as a "green" oxidant with co-catalysis of TBAI and FeCl3 in water.

The First ZnII-Catalyzed Oxidative Amidation of Benzyl Alcohols with Amines under Solvent-Free Conditions

The first zinc-catalyzed oxidative amidation of benzyl alcohols has been developed. Both aliphatic and aromatic amines can be tolerated and applied in this reaction. Various amides were prepared in good yields under solvent-free and mild conditions. Copyright

Kinetics and Mechanism of Aminolysis of Carbamates

The kinetics of the n-butylaminolysis of three series of mono- and disubstituted phenyl N-phenylcarbamates 1-3 have been studied spectrophotometrically under pseudo-first-order conditions in dioxane.The relation kobsd = k2 + k32 was found applicable for all esters.The rate constants k2 and k3 were correlated by the Hammett equation, and the corresponding activation parameters were determined.The reaction was found to be much more sensitive to a substituent on the leaving group (OAr) than to a substitutent on the amine portion (NHAr) of the esters.Results from crossover experiments revealed the absence of isocyanate intermediate.The mechanism of the aminolysis of carbamates is discussed in terms of these facts.

11a-Methano-TXA compounds

The present invention provides novel 11a-methano-TXA compounds and intermediates and processs for their preparation. Further provided are methods for using these novel TXA analogs as inhibitors of thromboxane synthetase, rendering these analogs useful for a variety of pharmacological purposes. These pharmacological uses include anti-inflammatory, anti-thromobitc, and anti-asthma indications.