3532-53-4

Upstream product

• 100-44-7 benzyl chloride 
• 102-01-2 N-phenylacetoacetamide 
• 620-79-1 Ethyl 2-benzylacetoacetate 
• 62-53-3 aniline 
• 3532-54-5 2-benzylidene-3-oxo-N-phenylbutanamide 
• 538-51-2 benzylidene phenylamine 
• 100-39-0 benzyl bromide 
• 87769-41-3 5-benzyl-2,2,6-trimethyl-4H-1,3-dioxin-4-one 

Downstream Products

• 124443-77-2 3-benzyl-4-methyl-quinolin-2-ol 
• 124443-77-2 3-Benzyl-4-methyl-2(1H)-quinolinone 
• 124443-74-9 N-<(2,4-Dinitrophenyl)thio>-3-benzyl-4-methyl-2(1H)-quinolinone 
• 1006375-61-6 5-benzyl-4-bromo-6-oxo-1-phenyl-1,6-dihydropyridine-3-carbaldehyde 
• 1006375-78-5 5-benzyl-4-chloro-6-oxo-1-phenyl-1,6-dihydropyridine-3-carbaldehyde 
• 1006375-91-2 2-benzyl-3-chloro-N-phenylbut-2-enamide 

Relevant academic research and scientific papers

A Formal [3+2] Annulation of β-Oxoamides and 3-Alkyl- or 3-Aryl-Substituted Prop-2-Ynyl Sulfonium Salts: Substrate-Controlled Chemoselective Synthesis of Substituted γ-Lactams and Furans

A substrate-controlled synthesis of substituted γ-lactams and furans has been developed via a formal [3+2] annulation of β-oxoamides and 3-alkyl/arylprop-2-ynyl sulfonium salts in the presence of cesium carbonate in a chemoselective manner. This novel pro

A facile and efficient synthesis of polyfunctionalized pyridin-2(1H)-ones from β-oxo amides under Vilsmeier conditions

(Chemical Equation Presented) A facile and efficient one-pot synthesis of polysubstituted pyridin-2(1H)-ones from a variety of β-oxo amides under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation and intramo

Torsional Barriers in Quinolinone Hydroxylamine and Sulfenamide Derivatives

The preparation of a 2-quinolinone hydroxylamine (N-(benzyloxy)-2(1H)-quinolinone) and sulfenamide derivatives of 2- and 4-quinolinone (N--3-benzyl-4-methyl-2(1H)-quinolinone and N--3-benzyl-2-methyl-4(1H)

Synthesis of β-Ketocarboxamide Derivatives Using 2,2-Dimethyl-2H,4H-1,3-dioxin-4-ones

Thermal reaction of 2,2-dimethyl-2H,4H-1,3-dioxin-4-ones (1) with amines was studied.Acylketenes 2, generated by heating of 1, reacted with anilines and benzylamine to give the corresponding β-ketocarboxamides (3,4, and 5) in good yields.The reaction of 1 with ammonia gave 3-amino-2-alkenamides (7), which were hydrolyzed to β-ketocarboxamides (6).The former products 7 were readily transformed to the 6-substituted 2-methyl-3H-pyrimidin-4-ones (9) via the 3-acetamido-2-alkenamides (8).Acylation of O-benzylhydroxylamine with 1 gave the β-ketohydroxamic acids 10.Debenzylation of 10 followed by cyclization gave rise to 5-alkyl-3-hydroxyisoxazoles (12).The reaction of 1 with amides gave the corresponding N-acetylated amides (13). Keywords --- 2H,4H-1,3-dioxin-4-one; thermal fragmentation; acylketene; acylation; carboxamide; hydroxamic acid; 3-hydroxyisoxazole; 3H-pyrimidin-4-one