353237-65-7

Basic information

• Product Name: 2-Cyano-N-methoxy-N-methyl-acetamide
• Synonyms: 2-Cyano-N-methoxy-N-methyl-acetamide
• CAS NO: 353237-65-7
• Molecular Formula: C₅H₈N₂O₂
• Molecular Weight: 128.12922
• Mol File: 353237-65-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Cyano-N-methoxy-N-methyl-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyano-N-methoxy-N-methyl-acetamide(353237-65-7)
• EPA Substance Registry System: 2-Cyano-N-methoxy-N-methyl-acetamide(353237-65-7)

Safety Data

• Hazardous Substances Data: 353237-65-7(Hazardous Substances Data)

Upstream product

• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 163625-27-2 N^α-formyl-N-methoxy-N-methyl-2-aminoacetamide 

Relevant articles and documents

Study of the chemoselectivity of Grignard reagent addition to substrates containing both nitrile and Weinreb amide functionalities

Several substrates containing both cyano and Weinreb amide functionalities have been synthesized to study the chemoselectivity of their reactions with organomagnesium bromides (ArMgBr and RMgBr). Excellent chemoselectivity towards the Weinreb amide was observed in most cases, even in the presence of excess Grignard reagent, affording cyano ketones in good-to-excellent yields. The reactions of various substrates containing both nitrile and Weinreb amide functionalities with Grignard reagents have been studied. The Weinreb amide reacts chemoselectively with excess Grignard reagent to give the corresponding cyano ketones in good yields. This chemoselectivity has been exploited for the synthesis of a key coumarin intermediate towards the 5-lipoxygenase inhibitor MK-0633. Copyright