353249-81-7

Upstream product

• 41904-39-6 3-chloro-benzeneacetyl chloride 
• 2199-43-1 ethyl 1H-pyrrole-2-carboxylate 
• 933786-11-9 ethyl 4-(2-(3-chlorophenyl)acetyl)-1H-pyrrole-2-carboxylate 

Downstream Products

• 933786-58-4 N-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide 
• 933786-58-4 N-((R)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide 
• 933786-58-4 N-((S)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide 

Relevant academic research and scientific papers

Flipped out: Structure-guided design of selective pyrazolylpyrrole ERK inhibitors

The Ras/Raf/MEK/ERK signal transduction is a key oncogenic pathway implicated in a variety of human cancers. We have identified a novel series of pyrazolylpyrroles as inhibitors of ERK. Aided by the discovery of two distinct binding modes for the pyrazoly