353260-19-2

Basic information

• Product Name: 2-[(3-fluorobenzyl)sulfanyl]-4(3H)-pyrimidinone
• Synonyms: 2-[(3-fluorobenzyl)sulfanyl]-4(3H)-pyrimidinone
• CAS NO: 353260-19-2
• Molecular Formula: C₁₁H₉FN₂OS
• Molecular Weight: 236.2653632
• Mol File: 353260-19-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[(3-fluorobenzyl)sulfanyl]-4(3H)-pyrimidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(3-fluorobenzyl)sulfanyl]-4(3H)-pyrimidinone(353260-19-2)
• EPA Substance Registry System: 2-[(3-fluorobenzyl)sulfanyl]-4(3H)-pyrimidinone(353260-19-2)

Safety Data

• Hazardous Substances Data: 353260-19-2(Hazardous Substances Data)

Upstream product

• 591-28-6 4-thiouracil 
• 456-42-8 m-fluorobenzyl chloride 
• 141-90-2 2-thiouracil 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 

Downstream Products

• 1373521-25-5 2-((2-(3-fluorobenzylthio)pyrimidin-4-yl)(allyl)amino)-N-cyclohexyl-2-phenylacetamide 
• 1373521-31-3 2-((2-(3-fluorobenzylthio)pyrimidin-4-yl)(allyl)amino)-N-cyclohexyl-3-methylbutanamide 
• 1373521-29-9 2-((2-(3-fluorobenzylthio)pyrimidin-4-yl)(allyl)amino)-N-cyclohexyl-4-methylpentanamide 
• 1373521-33-5 2-((2-(3-fluorobenzylthio)pyrimidin-4-yl)(allyl)amino)-N-tert-butylbutanamide 
• 1373521-27-7 2-((2-(3-fluorobenzylthio)pyrimidin-4-yl)(2-methoxyethyl)amino)-N-(4-methoxybenzyl)-2-phenylacetamide 
• 1373521-23-3 2-((2-(3-fluorobenzylthio)pyrimidin-4-yl)(2-methoxyethyl)amino)-N-(4-chlorobenzyl)-4-methylpentanamide 

Relevant articles and documents

4-Aminopyrimidine libraries from the Ugi-Smiles reaction of thiouracil

The Ugi-Smiles reaction of S-benzyl thiouracil have been exploited in several three-step sequences for the preparation of aminopyrimidine libraries with high diversity. After the 4-component coupling, oxidation of the thioether to sulfone is followed by displacement of the latter by various carbon-centered nucleophiles (cyanide, malonate, boronic acids) or amines. The efficiency of the whole sequence was further demonstrated with one-pot procedures.