353281-36-4Relevant academic research and scientific papers
Novel 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles as PPARγ agonists
Blanc-Delmas, Elodie,Lebegue, Nicolas,Wallez, Valerie,Leclerc, Veronique,Yous, Said,Carato, Pascal,Farce, Amaury,Bennejean, Caroline,Renard, Pierre,Caignard, Daniel-Henri,Audinot-Bouchez, Valerie,Chomarat, Pascale,Boutin, Jean,Hennuyer, Nathalie,Louche, Katie,Carmona, Maria Carmen,Staels, Bart,Penicaud, Luc,Casteilla, Louis,Lonchampt, Michel,Dacquet, Catherine,Chavatte, Philippe,Berthelot, Pascal,Lesieur, Daniel
, p. 7377 - 7391 (2007/10/03)
A series of 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles has been synthesized and tested for PPARγ agonist activity. SAR were developed and revealed that 6-acyl-2(3H)-benzothiazolone derivatives with 1,3-dicarbonyl group were the most potent. IP administration of compound 22 exhibited comparable levels of glucose and triglyceride correction to PO administration of rosiglitazone in the ob/ob mouse studies.
Novel heterocyclic derivatives, preparation method and pharmaceutical compositions containing same
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, (2008/06/13)
Compounds of formula (I): wherein: X represents an oxygen atom or a sulphur atom or a group CH2 or R1 and R2 represent a hydrogen atom, or a group as defined in the description, A represents an alkylene chain as described
