353301-95-8

Upstream product

• 100-39-0 benzyl bromide 
• 108999-10-6 Methyl 5-acetamido-2,3,5-trideoxy-8,9-O-isopropylidene-D-glycero-D-galacto-non-2-enopyranosonate 
• 67670-69-3 N-acetyl-4,7,8,9-tetra-O-acetyl-2-chloro-2-deoxyneuraminic acid methyl ester 
• 73960-72-2 methyl-2,3-didehydro-4,7,8,9-tetra-O-acetyl-N-acetylneuraminate 
• 25875-99-4 methyl 5-acetamido-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enonate 

Downstream Products

• 353301-93-6 Methyl 5-acetamido-4-O-benzyl-3,5-dideoxy-8,9-O-isopropylidene-3-phenylthio-β-D-erythro-L-gluco-2-nonulopyranosonate-diethylphosphite 
• 353301-97-0 Methyl 5-acetamido-4-O-benzyl-3,5-dideoxy-8,9-O-isopropylidene-3-phenylthio-β-D-erythro-L-gluco-2-nonulopyranosonate 
• 353301-96-9 Methyl 5-acetamido-4-O-benzyl-3-bromo-3,5-dideoxy-8,9-O-isopropylidene-β-D-erythro-L-manno-2-nonulopyranosonate 

Relevant academic research and scientific papers

Synthesis of ganglioside GD3 and its comparison with bovine GD3 with regard to oligodendrocyte apoptosis mitochondrial damage

2,3-Dehydroneuraminic acid derivative 5 was transformed in five efficient steps into sialyl donor 2, which has a phenylthio group on the β-side of the 3-position for anchimeric assistance and a diethyl phosphite residue as leaving group at the anomeric ca

Synthesis and evaluation of 4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneuraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activity

The X-ray crystal structure of the paramyxoviral surface glycoprotein haemagglutinin-neuraminidase (HN) from Newcastle Disease virus was used as a template to design inhibitors of the HN from human parainfluenza virus type-3 (hPIV-3). 4-O-Alkylated derivatives of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (Neu5Ac2en), accessed from 8,9-O-isopropylidenated-Neu5Ac2en1Me, were found to inhibit the sialidase (neuraminidase) activity of hPIV-3 (strain C243) in the range of 3-30 μM. This is comparable or improved activity compared to the parent 4-hydroxy compound.